5096-73-1

Basic information

• Product Name: 6-Chloropyridazine-3-carboxylic acid
• Synonyms: 3-chloropyridazine-6-carboxylic acid;3-pyridazinecarboxylic acid, 6-chloro-;6-Chloropyridazine-3-caSNoxylic acid ;REF DUPL: 3-Chloropyridazine-6-carboxylic acid;3-Chloropyridazine-6-carb...;3-Carboxy-6-chloropyridazine;6-CHLORO-3-CARBOXY-PYRIDAZINE;3-Carboxy-6-chloropyridazine, 3-Carboxy-6-chloro-1,2-diazine
• CAS NO: 5096-73-1
• Molecular Formula: C₅H₃ClN₂O₂
• Molecular Weight: 158.54
• Product Categories: Carboxylic Acids;Pyrazines, Pyrimidines & Pyridazines;pyridazine;Building Blocks;Pyridazine series;Carboxylic Acids;Pyrazines, Pyrimidines & Pyridazines
• Mol File: 5096-73-1.mol
• Article Data: 16

Chemical Properties

• Melting Point: 146 °C
• Boiling Point: 429 °C at 760 mmHg
• Flash Point: 213.2 °C
• Appearance: White to cream/Crystalline Powder
• Density: 1.58 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.598
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 2.68±0.10(Predicted)
• CAS DataBase Reference: 6-Chloropyridazine-3-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Chloropyridazine-3-carboxylic acid(5096-73-1)
• EPA Substance Registry System: 6-Chloropyridazine-3-carboxylic acid(5096-73-1)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 5096-73-1(Hazardous Substances Data)

Usage

Description

6-Chloropyridazine-3-carboxylic acid is a pyradazine derivative characterized by the presence of a chloro substituent at the 6th position and a carboxylic acid group at the 3rd position. It is a synthetic organic compound with potential applications in various fields.

Uses

Used in Pharmaceutical Industry:
6-Chloropyridazine-3-carboxylic acid is used as a key intermediate in the synthesis of stearoyl-CoA desaturase inhibitors. These inhibitors are important for the development of drugs targeting metabolic disorders and lipid metabolism, as they can modulate the activity of enzymes involved in fatty acid synthesis and breakdown.
Used in Chemical Research:
6-Chloropyridazine-3-carboxylic acid can also be utilized as a building block in the synthesis of various pyradazine-based compounds with potential applications in medicinal chemistry, materials science, and other research areas. Its unique structural features allow for further functionalization and modification to create novel molecules with specific properties and functions.

InChI:InChI=1/C5H3ClN2O2/c6-4-2-1-3(5(9)10)7-8-4/h1-2H,(H,9,10)

Upstream product

• 1121-79-5 3-chloro-6-methylpyridazine 
• 37972-69-3 6-oxo-1,6-dihydropyridazine-3-carboxylic acid 
• 13327-27-0 6-Methylpyridazin-3(2H)-on 
• 7758-19-2 sodium chlorite 
• 303085-53-2 6-chloro-3-pyridazinecarboxaldehyde 
• 75-05-8 acetonitrile 
• 75680-92-1 6-chloro-3-pyridazinecarboxylic acid ethyl ester 
• 65202-50-8 methyl 6-chloro-3-pyridazinecarboxylate 

Downstream Products

• 59772-58-6 3-aminopyridazine-6-carboxylic acid 
• 74163-11-4 8-chloro-10-oxo-10H-pyridazino<6,1-b>-quinazoline-2-carboxylic acid 
• 6531-04-0 6-chloro-pyridazine-3-carbonyl chloride 
• 98021-37-5 3-aminopyridazine-6-carboxamide 
• 146233-35-4 3-amino-6-benzoylpyridazine 
• 146233-32-1 3-(6-chloropyridazinyl) phenyl ketone 
• 146233-34-3 3-chloro-6-(2-thienylcarbonyl)pyridazine 
• 146233-36-5 3-amino-6-(fluorobenzoyl)pyridazine 
• 146233-33-2 3-(4-fluorobenzoyl)-6-chloropyridazine 
• 1026969-79-8 (4-Fluoro-phenyl)-(6-isocyanato-pyridazin-3-yl)-methanone 
• 146233-49-0 methyl 6-carboxamidoimidazo<1,2-b>pyridazine-2-carbamate 
• 146233-41-2 methyl 6-(2-thienylcarbonyl)imidazo<1,2-b>pyridazine-2-carbamate 
• 840488-85-9 6-chloropyridazine-3-carboxylic acid (2-cyclopropylethyl)amide 
• 938137-87-2 6-(4-chloro-phenylamino)-pyridazine-3-carboxylic acid 

Relevant articles and documents

COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF ANDROGEN RECEPTOR

This disclosure pertains to compounds, the preparation thereof, and the use of these compounds in the treatment of prostate cancer, including metastatic and/or castrate-resistant prostate cancer, in subjects in need thereof.

6-methoxy diazine-3-carboxylic acid synthesis process

The present invention discloses a 6-methoxy diazine-3-carboxylic acid synthesis process, which comprises: 1) under ice bath, adding 3-chloro-6-methyl diazine to sulfuric acid, adding an oxidizing agent under stirring, carrying out a reaction at a temperature of 50-90 DEG C, cooling, adding ice water, diluting, extracting, combining the extraction liquid, drying, carrying out pressure reducing to achieve a dried state, and re-crystallizing the residue to obtain 6-chloro diazine-3-carboxylic acid; and 2) adding sodium methoxide and the 6-chloro diazine-3-carboxylic acid to the solvent in a stirring manner, carrying out a reflux reaction on the system, carrying out pressure reducing on the reaction liquid to remove the excess solvent, adding ice water, adjusting the pH value with concentrated hydrochloric acid, standing overnight, filtering, and re-crystallizing the filter cake by using water to obtain the 6-methoxy diazine-3-carboxylic acid. According to the present invention, the starting raw material is changed, is subjected to the domestic industrial production, and is easy to obtain, the synthetic steps are reduced, the operation process is reduced, and the 6-methoxy diazine-3-carboxylic acid synthesis is suitable for industrial production.

SUBSTITUTED BICYCLIC AZA-HETEROCYCLES AND ANALOGUES AS SIRTUIN MODULATORS

Provided herein are novel substituted bicyclic aza-heterocycle sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided, are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.