50966-74-0Relevant articles and documents
CYCLOMETALLATION OF A PYRROLE RING OF 2-(1-PYRROLYL)PYRIDINE WITH PALLADIUM(II) AND RHODIUM(III)
Nonoyama, Matsuo
, p. 407 - 412 (1984)
2-(1-Pyrrolyl)pyridine (Hplp) is cyclometallated with lithium tetrachloropalladate(II) and hexahalogenotetrakis(tri-n-butylphosphine)dirhodium(III) to give 2 and (X=Cl, Br; PBu3=tri-n-butylphosphine), respectively, where deprotonated plp is coordinated via the pyridine-N and pyrrole-2C atoms forming a five-membered metallacycle. 2 reacts with pyridine (py) and with PBu3 to form the adducts (L=py, PBu3) and with acetylacetone (Hacac) to afford the complex .Metathesis of with excess lithium iodide gives a mixed halogeno complex .These complexes are characterized spectroscopically.
Ultrasound-assisted bismuth nitrate-induced green synthesis of novel pyrrole derivatives and their biological evaluation as anticancer agents
Bandyopadhyay, Debasish,Mukherjee, Sanghamitra,Granados, Jose C.,Short, John D.,Banik, Bimal K.
, p. 209 - 215 (2012)
A series of novel N-substituted pyrrole derivatives have been designed and synthesized following ultrasound-assisted and bismuth nitrate-catalyzed eco-friendly route. This reaction has also provided a general method to prepare diverse varieties of N-substituted pyrroles with less nucleophilic polyaromatic amines. Based on 1H NMR spectroscopy, a plausible mechanistic pathway has been advanced. Cytotoxicity of some selected N-substituted pyrrole derivatives has been evaluated in vitro in a panel of mammalian cancer cell lines which includes liver cancer cell lines (HepG2 and Hepa1-6), colon cancer cell lines (HT-29 and Caco-2), a cervical cancer cell line (HeLa) and NIH3T3 cells. Two compounds, 5-(1H-pyrrol-1-yl)-1,10-phenanthroline (9) and 1-(phenanthren-2-yl)-1H-pyrrole (10) have shown good cytotoxicity against some cancer cell lines. Furthermore, these compounds have exhibited cytotoxic specificity against liver cancer cell lines in vitro when compared with normal cultured primary hepatocytes.
Cobalt-Catalyzed Enantioselective Hydroarylation of 1,6-Enynes
Whyte, Andrew,Torelli, Alexa,Mirabi, Bijan,Prieto, Liher,Rodríguez, José F.,Lautens, Mark
supporting information, p. 9510 - 9517 (2020/05/18)
An asymmetric hydroarylative cyclization of enynes involving a C-H bond cleavage is reported. The cobalt-catalyzed cascade generates three new bonds in an atom-economical fashion. The products were obtained in excellent yields and excellent enantioselectivities as single diastereo- and regioisomers. Preliminary mechanistic studies indicate that the reaction shows no intermolecular C-H crossover. This work highlights the potential of cobalt catalysis in C-H bond functionalization and enantioselective domino reactivity.
Cu(II)-catalyzed C-N coupling of (hetero)aryl halides and N-Nucleophiles promoted by α-benzoin oxime
Yuan, Chunling,Zhang, Lei,Zhao, Yingdai
, (2019/11/28)
We first reported the new application of a translate metal chelating ligand α-benzoin oxime for improving Cu-catalyzed C-N coupling reactions. The system could catalyse coupling reactions of (hetero)aryl halides with a wide of nucleophiles (e.g., azoles, piperidine, pyrrolidine and amino acids) in moderate to excellent yields. The protocol allows rapid access to the most common scaαolds found in FDA-approved pharmaceuticals.