51-74-1

Basic information

• Product Name: Histamine phosphate
• Synonyms: HISTAMINEPHOSPHATE,USP;2-(4-Imidazolyl)ethylamine diphosphate salt, 2-(4-Imidazolyl)ethylamine monohydrate diphosphate salt, Histamine monohydrate diphosphate salt;2-(4-Imidazolyl)ethylamine diphosphate salt monohydrate;Histamine diphosphate salt monohydrat;Histamine bisphosphate monohydrate,2-(4-Imidazolyl)ethylamine diphosphate salt monohydrate, 2-(4-Imidazolyl)ethylamine diphosphate salt, Histamine diphosphate salt monohydrate;Histamine diphosphat;Histapon;HistaMine Diphosphate
• CAS NO: 51-74-1
• Molecular Formula: C5H12N3O4P
• Molecular Weight: 209.14
• EINECS: 200-118-4
• Product Categories: Other APIs;Inhibitors
• Mol File: 51-74-1.mol
• Article Data: 0

Chemical Properties

• Melting Point: 128-132 °C
• Boiling Point: 331 °C at 760 mmHg
• Flash Point: 180.3 °C
• Appearance: White/Powder
• Storage Temp.: −20°C
• Water Solubility: Soluble in water.
• Sensitive: Hygroscopic
• Merck: 14,4719
• BRN: 3744619
• CAS DataBase Reference: Histamine phosphate(CAS DataBase Reference)
• NIST Chemistry Reference: Histamine phosphate(51-74-1)
• EPA Substance Registry System: Histamine phosphate(51-74-1)

Safety Data

• Hazard Codes: Xn
• Statements: 20/21/22-36/37/38-42/43-41-37/38-22
• Safety Statements: 26-36-45-36/37/39-22
• WGK Germany: 3
• RTECS: NI5425000
• F: 3-10
• TSCA: Yes
• Hazardous Substances Data: 51-74-1(Hazardous Substances Data)

Usage

Description

Histamine phosphate, also known as histamine diphosphate, is a phosphate salt derived from histamine, an imidazole-containing heterocyclic compound. It is a white crystalline substance with a monoclinic crystal structure, belonging to the P21/c space group, and exhibits O-H...O and N-H...O hydrogen bonds. Histamine phosphate is recognized for its potent agonist activity on histamine receptors and its ability to activate nitric oxide synthetase, making it a potent vasodilator.

Uses

1. Pharmaceutical Industry:
Histamine phosphate is used as a potent histamine receptor agonist for various pharmaceutical applications. It plays a crucial role in the development and testing of drugs targeting histamine receptors, which are involved in numerous physiological processes, including immune response, gastric acid secretion, and neurotransmission.
2. Cardiovascular Applications:
In the field of cardiovascular medicine, histamine phosphate is used as a potent vasodilator. Its ability to activate nitric oxide synthetase leads to the relaxation of blood vessels, which can help in treating conditions characterized by increased vascular resistance, such as hypertension and certain heart diseases.
3. Chemical Synthesis:
Histamine phosphate serves as an important building block in chemical synthesis, particularly for the development of new compounds with potential applications in various industries, including pharmaceuticals, agrochemicals, and materials science.
4. Research and Development:
In the research and development sector, histamine phosphate is utilized as a key compound for studying the structure, function, and regulation of histamine receptors. This knowledge can contribute to the development of novel therapeutic strategies for various diseases and conditions.

InChI:InChI=1/C5H9N3.H4O7P2/c6-2-1-5-3-7-4-8-5;1-8(2,3)7-9(4,5)6/h3-4H,1-2,6H2,(H,7,8);(H2,1,2,3)(H2,4,5,6)