51012-32-9 Usage
Originator
Tiapridal,Delagrange,France,1977
Uses
Tiapride hydrochloride is a D2DR and D3DR inhibitor; Anti-psychotic agent and alternative treatment for Tourette’s syndrome.
Manufacturing Process
5 g of 2-methoxy-5-methylsulfonylbenzoic acid, 50 ml of dioxan, 3.02 ml of
triethylamine and 3 g of isobutyl chloroformate were introduced into a 250 ml
balloon flask at ambient temperature.
After the mixture had been stirred for 30 minutes, 3 g of N,N_x0002_diethylethylenediamine were added. The reaction mixture was stirred for 6
hours and the solvents were evaporated under vacuum.
The residue was dissolved in 50 ml of water and the solution was made
alkaline with sodium hydroxide. The precipitate formed was filtered, washed
and dried in a drying oven at 60°C. 6 g of N-(diethylaminoethyl)-2-methoxy-
5-methylsulfonylbenzamide (melting point: 124°C to 125°C) was produced.
Brand name
Tiapride Hydrochloride is JAN.
Therapeutic Function
Antiemetic
Check Digit Verification of cas no
The CAS Registry Mumber 51012-32-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,1,0,1 and 2 respectively; the second part has 2 digits, 3 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 51012-32:
(7*5)+(6*1)+(5*0)+(4*1)+(3*2)+(2*3)+(1*2)=59
59 % 10 = 9
So 51012-32-9 is a valid CAS Registry Number.
InChI:InChI=1/C15H24N2O4S.ClH/c1-5-17(6-2)10-9-16-15(18)13-11-12(22(4,19)20)7-8-14(13)21-3;/h7-8,11H,5-6,9-10H2,1-4H3,(H,16,18);1H
51012-32-9Relevant articles and documents
Direct Amidation of Carboxylic Acids through an Active α-Acyl Enol Ester Intermediate
Xu, Xianjun,Feng, Huangdi,Huang, Liliang,Liu, Xiaohui
, p. 7962 - 7969 (2018/06/18)
The development of a highly efficient and simple protocol for the direct amidation of carboxylic acids is described employing ynoates as novel coupling reagents. The transformation proceeds in good to excellent yields via in situ α-acyl enol ester intermediates formation under mild reaction conditions. This useful method has been demonstrated for a range of substrates to provide a succinct access to structurally diverse amides, including key intermediates of glibenclamide, tiapride hydrochloride, and nateglinide, and can be conducted on a mole scale.
