51021-89-7Relevant articles and documents
Fluoride-Catalyzed Esterification of Amides
Wu, Hongxiang,Guo, Weijie,Daniel, Stelck,Li, Yue,Liu, Chao,Zeng, Zhuo
, p. 3444 - 3447 (2018)
In recent years, it has been demonstrated that amide carbon–nitrogen bonds can be activated and selectively cleaved using transition metal catalysts. However, these methodologies have been restricted to specific amides; a one-to-one relationship exists between the catalytic system and the amides and also uses large amounts of transition-metal catalysts and ligands. Hence, we now report a general strategy for esterification of common amides using fluoride as a catalyst. This method shows high functional group tolerance, and notably it requires only a slight excess of the alcohol nucleophile, which is a rare case in transition-metal-free amide transformations. Moreover, this approach may provide a new understanding for further studies on esterification of amides and is expected to stimulate the development of alternative methods for direct functionalization of amides.
SUBSTITUTION REACTIONS WITH ORGANOALUMINUM COMPOUNDS. VIII. A NEW VERSION OF THE SYNTHESIS OF 2-ACYL-1,3-DITHIANES
Tolstikov, G. A.,Spivak, A. Yu.,Kresteleva, I. V.,Vyrypaev, E. M.
, p. 2111 - 2116 (2007/10/02)
The reaction of 2-alumino-1,3-dithianes with acyl chlorides takes place in competing C- and S-acylation directions, the ratio of which depends substantially on the structure of the reagents.The C-acylation is a new version of the synthesis of 2-acyl-1,3-d
