51096-49-2

Basic information

• Product Name: (S)-(+)-2-BENZYLAMINO-1-PHENYLETHANOL
• Synonyms: (S)-(+)-2-Benzylamino-1-phenylethanol;(S)-2-Benzylamino-1-phenylethanol,99%e.e.
• CAS NO: 51096-49-2
• Molecular Formula: C₁₅H₁₇NO
• Molecular Weight: 227.3
• Product Categories: Amino Alcohols;Chiral Building Blocks;Organic Building Blocks
• Mol File: 51096-49-2.mol
• Article Data: 64

Chemical Properties

• Melting Point: 115-118 °C(lit.)
• Boiling Point: 375.2 °C at 760 mmHg
• Flash Point: 127.3 °C
• Appearance: /
• Density: 1.1 g/cm³
• Vapor Pressure: 2.69E-06mmHg at 25°C
• Refractive Index: 1.593
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 13.78±0.20(Predicted)
• CAS DataBase Reference: (S)-(+)-2-BENZYLAMINO-1-PHENYLETHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-(+)-2-BENZYLAMINO-1-PHENYLETHANOL(51096-49-2)
• EPA Substance Registry System: (S)-(+)-2-BENZYLAMINO-1-PHENYLETHANOL(51096-49-2)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 51096-49-2(Hazardous Substances Data)

Usage

Description

(S)-(+)-2-Benzylamino-1-phenylethanol is an organic compound with the molecular formula C15H17NO. It is a white powder and is known for its unique chemical properties and applications in various industries.

Uses

Used in Pharmaceutical Industry:
(S)-(+)-2-Benzylamino-1-phenylethanol is used as an intermediate in the synthesis of aziridines using α-amino and α-amido ketones via asymmetric transfer hydrogenation reaction. This process is crucial in the development of new pharmaceutical compounds with potential therapeutic applications.
Used in Chemical Synthesis:
(S)-2-Benzylamino-1-phenylethanol serves as a starting material in the preparation of iron catalysts applicable in the oxidation of secondary alcohols and benzylic methylene groups. These catalysts play a vital role in various chemical reactions and processes, contributing to the synthesis of a wide range of chemical products.

InChI:InChI=1/C15H17NO/c17-15(14-9-5-2-6-10-14)12-16-11-13-7-3-1-4-8-13/h1-10,15-17H,11-12H2/t15-/m1/s1

Upstream product

• 96-09-3 styrene oxide 
• 100-46-9 benzylamine 
• 92-71-7 2,5-diphenyloxazole 
• 50606-93-4 α-(N-Benzylamino)acetophenone 
• 3282-32-4 2-diazo-acetophenone 
• 100-52-7 benzaldehyde 
• 7568-93-6 2-Amino-1-phenylethanol 
• 125582-79-8 C₁₉H₃₅NPb 
• 22020-69-5 oxytriphine 
• 25558-12-7 2-(benzylideneamino)-1-phenylethan-1-ol 
• 91850-97-4 Benzaldehyd-N-benzylimin 
• 163799-40-4 2-(Benzylamino)-1-<(tert-butyldimethylsilyl)oxy>-1-phenylethane 
• 70-11-1 α-bromoacetophenone 
• 64-17-5 ethanol 

Downstream Products

• 17125-28-9 N-Benzyl-2-brom-2-phenyl-aethylamin 
• 72702-58-0 2--1-phenylethanol 
• 104143-95-5 3-benzyl-5-phenyl-1,3-oxazolidine 
• 75626-12-9 4-phenyl-1,2,3,4-tetrahydroisoquinoline 
• 27159-38-2 N-benzyl-2-phenylaziridine 
• 56203-53-3 1-[Benzyl-(2-hydroxy-2-phenyl-ethyl)-amino]-propan-2-one 
• 158663-83-3 2-[Benzyl-(2-hydroxy-2-phenyl-ethyl)-amino]-1-phenyl-ethanone 
• 185376-67-4 3-[Benzyl-(2-hydroxy-2-phenyl-ethyl)-amino]-1-phenyl-propan-1-one 
• 185376-77-6 (2-methoxy-2-phenylethyl)phenylmethyl carbamic acid 1,1-dimethylethyl ester 
• 215391-95-0 4-[Benzyl-(2-hydroxy-2-phenyl-ethyl)-amino]-1-phenyl-butan-1-one 
• 215391-96-1 rac-2-(N-tert-Butoxycarbonyl-N-benzylamino)-1-phenylethanol 
• 185376-72-1 3-[Benzyl-(2-methoxy-2-phenyl-ethyl)-amino]-1-phenyl-propan-1-one 
• 28102-51-4 (4S*)-N-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline 
• 89160-45-2 (4R)-(+)-4-phenyl-1,2,3,4-tetrahydroisoquinoline 

Relevant articles and documents

Synthesis, characterization and catalytic application of Bi2S3 microspheres for Suzuki-Miyaura cross-coupling reaction and chemoselective ring opening of epoxides

Bismuth sulfide (Bi2S3) prepared using L-cysteine, which served as both the sulfur source and the directing molecule for the formation of Bi2S3 as heterogeneous catalyst through solvothermal method. The prepared catalyst was examined by various techniques such as XRD, BET, FE-SEM, TEM, and TGA analysis. The results and analysis revealed that bismuth microspheres have better catalytic behavior for the preparation of biphenyl in water as a greenest solvent and for the ring opening of epoxides by nucleophiles including amines, alcohol, and thiol compared to pure Bi(NO3)3. 3H2O under solvent-free condition. Moreover, the novel catalyst could be recovered and reusedat least four times without loss of its catalytic activity.

Highly regioselective ring-opening of epoxides with amines: A metal- A nd solvent-free protocol for the synthesis of β-amino alcohols

We herein report a metal- A nd solvent-free acetic acid-mediated ring-opening reaction of epoxides with amines. This process provides β-amino alcohols in high yields with excellent regioselectivity. Importantly, this epoxide ring-opening protocol can be used for the introduction of amines in natural products during late-stage transformations.

OLIGONUCLEOTIDE AND NUCLEIC ACID SYNTHESIS

The present invention relates to methods for the high fidelity synthesis of oligonucleotides and polynucleotides on a solid surface. In particular, the invention relates to methods of synthesising oligonucleotides, polynucleotides, and doublestranded polynucleotides/nucleic acids, such as DNA and XNA, wherein the process comprises thermally controlled deprotection steps at the 5'-OH of previously coupled nucleosides or nucleotides at selected sites on the surface of the substrate.