511544-87-9

Basic information

• Product Name: α-tert-butyl-N-[4-(methylamino)benzoyl]-L-glutamate
• Synonyms: α-tert-butyl-N-[4-(methylamino)benzoyl]-L-glutamate
• CAS NO: 511544-87-9
• Molecular Weight: 336.388
• Mol File: 511544-87-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: α-tert-butyl-N-[4-(methylamino)benzoyl]-L-glutamate(CAS DataBase Reference)
• NIST Chemistry Reference: α-tert-butyl-N-[4-(methylamino)benzoyl]-L-glutamate(511544-87-9)
• EPA Substance Registry System: α-tert-butyl-N-[4-(methylamino)benzoyl]-L-glutamate(511544-87-9)

Safety Data

• Hazardous Substances Data: 511544-87-9(Hazardous Substances Data)

Upstream product

• 66891-86-9 benzyl (4-(chlorocarbonyl)phenyl)(methyl)carbamate 
• 2528-30-5 4-<<(benzyloxy)carbonyl>methylamino>benzoic acid 
• 511544-85-7 α-tert-butyl N-[4-(N-benzyloxycarbonyl-N-methyl)aminobenzoyl]-L-glutamate 

Downstream Products

• 79640-70-3 (S)-5-(tert-butoxy)-4-(4-(((2,4-diaminopteridin-6-yl)methyl)(methyl)amino)benzamido)-5-oxopentanoic acid 
• 181040-33-5 N^α-[[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-(α-tert-butoxy)glutamoyl]-N-[2-[(1-oxohexadecyl)oxy]-1,1-bis[[(1-oxohexadecyl)oxy]methyl]ethyl]glycinamide 
• 181040-49-3 N^α-[[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-(α-tert-butoxy)glutamoyl]-N-[1-hydroxymethyl-2-[(1-oxohexadecyl)oxy]-1-[(1-oxohexadecyl)oxymethyl]ethyl]glycinamide 
• 511544-99-3 N^α-[[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-(α-tert-butoxy)glutamoyl]-N-[1,1-bis(hydroxymethyl)-2-[(1-oxohexadecyl)oxy]ethyl]glycinamide 
• 181040-47-1 N^α-[[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-(α-tert-butoxy)glutamoyl]-N-[2-hydroxy-1,1-bis(hydroxymethyl)ethyl]glycinamide 

Relevant articles and documents

Total synthesis of methotrexate-γ-TRIS-fatty acid conjugates

Several routes for the regiospecific synthesis of lipophilic γ-conjugates of methotrexate are described. Coupling of methotrexate-α-tert-butyl ester with glycyl-TRIS-(mono-/di-/tri-)palmitate followed by trifluoroacetic acid cleavage of the α-protection a