51230-16-1Relevant articles and documents
AGRICULTURAL CHEMICALS
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Page/Page column 56, (2019/08/08)
The present invention relates to picolinic acid derivatives that are useful in treating fungal diseases ofplants.
INHIBITORS OF BRUTON'S TYROSINE KINASE
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Page/Page column 48; 50; 53; 64, (2015/06/25)
This application discloses compounds according to generic Formula (I): wherein all variables are defined as described herein, which inhibit Btk. The compounds disclosed herein are useful to modulate the activity of Btk and treat diseases associated with excessive Btk activity. The compounds are useful for the treatment of oncological, auto-immune, and inflammatory diseases caused by aberrant B-cell activation. Also disclosed are compositions containing compounds of Formula I and at least one carrier, diluent or excipient.
The Smiles Rearrangement of 2-Aryloxy-5-nitrophenoxides. Attempted Routes to Benzoxirens and Tribenzotrioxonins
Ramsden, Christopher A.
, p. 2456 - 2463 (2007/10/02)
Formation of dibenzo-p-dioxins by the pyrolysis of 2-halogenophenoxides does not appear to involve intermediate benzoxirens.Thermal self-condensation to potassium 2-bromo-5-nitrophenoxide (1b) gave a mixture of 2,7- and 2,8-dinitrobenzo-p-dioxins (6d) and (6e).The mechanism of formation of the 2,8-isomer (6e) is shown to involve Smiles rearrangement of potassium 2-(2-bromo-5-nitrophenoxy)-5-nitrophenoxide (9a).Further examples of Smiles rearrangements of 2-aryloxy-5-nitrophenoxides and an attempted synthesis of the tribenzotrioxonin derivatives (16) are described.