51333-05-2 Usage
Description
21-Acetoxy-11β-hydroxy-16α,17α-propylmethylenedioxpregna-1,4-diene-3,20-dione, also known as Budesonide EP Impurity K, is a non-halogenated glucocorticoid that is structurally related to triamcinolone hexacetonide. It is characterized by its white foam appearance and is primarily recognized for its anti-inflammatory properties.
Uses
Used in Pharmaceutical Industry:
21-Acetoxy-11β-hydroxy-16α,17α-propylmethylenedioxpregna-1,4-diene-3,20-dione is used as an anti-inflammatory agent for the treatment of various inflammation-related conditions. Its glucocorticoid nature allows it to modulate the immune system and reduce inflammation, making it a valuable compound in the development of medications for inflammatory diseases.
Used in Respiratory Treatment:
In the pharmaceutical industry, 21-Acetoxy-11β-hydroxy-16α,17α-propylmethylenedioxpregna-1,4-diene-3,20-dione is also used as an impurity of Budesonide (B689460), a non-halogenated glucocorticoid intended for the local treatment of lung diseases. Its application in this context is aimed at managing inflammation in the respiratory system, providing relief for patients suffering from conditions such as asthma or chronic obstructive pulmonary disease (COPD).
Chemical Properties:
The chemical properties of 21-Acetoxy-11β-hydroxy-16α,17α-propylmethylenedioxpregna-1,4-diene-3,20-dione include its appearance as a white foam, which is indicative of its glucocorticoid nature and its potential for use in the pharmaceutical industry.
Check Digit Verification of cas no
The CAS Registry Mumber 51333-05-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,1,3,3 and 3 respectively; the second part has 2 digits, 0 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 51333-05:
(7*5)+(6*1)+(5*3)+(4*3)+(3*3)+(2*0)+(1*5)=82
82 % 10 = 2
So 51333-05-2 is a valid CAS Registry Number.
51333-05-2Relevant articles and documents
A preparation method of budesonide
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Paragraph 0061; 0062; 0063; 0072, (2017/08/25)
The invention discloses a budesonide preparing method. Prednisone I and acetic anhydride II react to produce 17,21-diacetoxy-1,4-pregnane diene-3,11,20-triketone III, the III is degreased in an anhydrous solvent to obtain 21-acetoxyl group-1,4,16-pregnane diene-3,11,20-triketone IV, the IV is oxidized to obtain 16alpha,17alpha-dyhydroxy-21-acetoxyl-1,4-pregnane diene-3,11,20-triketone V, the V and n-butyl aldehyde VI are condensed to obtain 16alpha,17alpha-22(R,S) propyl methylenedioxy-21-acetoxyl group-1,4-pregnane diene-3,11,20-triketone VII, the VII is reduced to obtain 16alpha,17alpha-22(R,S) propyl methylenedioxy-11beta-hydroxyl-21-acetoxyl group-1,4-pregnane diene-3,20-diketone VIII, the VIII is subjected to base catalysis to obtain budesonide IX. The budesonide preparing method is suitable for industrial production.
A kind of budesonide S isomer R isomer method of preparation
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Paragraph 0008; 0018, (2017/01/12)
The invention discloses a method for preparing an R-isomer by using an S-isomer of budesonide. The method comprises the steps: enabling budesonide and acetic anhydride to be subjected to esterification reaction to obtain budesonide acetate; then, carrying out oxidative ring cleavage under the action of a strong oxidant to obtain 16-alpha hydroxyprednisonlone acetate; and condensing butyraldehyde and the 16-alpha hydroxyprednisonlone acetate to obtain budesonide acetate, and hydrolyzing to obtain R-budesonide. The method disclosed by the invention is high in conversion rate, high in yield and capable of effectively converting the S-isomer of the budesonide into the R-isomer.