5142-22-3 Usage
Description
1-METHYLADENINE, also known as N1-Methyladenine, is an organic compound derived from adenine with a methyl group substitution at the N-1 position. It is characterized by its pale yellow or beige crystalline powder appearance. This modification of adenine may have potential applications in various fields due to its unique chemical properties.
Uses
Used in Pharmaceutical Industry:
1-METHYLADENINE is used as a chemical intermediate for the synthesis of various pharmaceutical compounds. Its unique structure allows it to be a key component in the development of new drugs targeting specific biological pathways.
Used in Research and Development:
1-METHYLADENINE serves as an important research tool in the field of biochemistry and molecular biology. It can be utilized in the study of nucleic acid structure, function, and interactions, as well as in the development of novel nucleic acid-based therapeutics.
Used in Chemical Synthesis:
As a modified nucleobase, 1-METHYLADENINE can be employed in the synthesis of various complex organic molecules, including those with potential applications in materials science, nanotechnology, and other advanced fields.
Check Digit Verification of cas no
The CAS Registry Mumber 5142-22-3 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,1,4 and 2 respectively; the second part has 2 digits, 2 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 5142-22:
(6*5)+(5*1)+(4*4)+(3*2)+(2*2)+(1*2)=63
63 % 10 = 3
So 5142-22-3 is a valid CAS Registry Number.
InChI:InChI=1/C6H7N5/c1-11-3-10-6-4(5(11)7)8-2-9-6/h2-3,7H,1H3,(H,8,9)
5142-22-3Relevant articles and documents
Purines. LXI. An attempted synthesis of 2'-deoxy-7-methyladenosine: Glycosidic hydrolyses of the N6-methoxy derivative and 2'-deoxy-N(x)- methyladenosines
Fujii,Saito,Iguchi
, p. 495 - 499 (2007/10/02)
In an attempt to synthesize 2'-deoxy-7-methyladenosine (5b), 2'-deoxy- N6-methoxyadenosine (13b) was treated with MeI in AcNMe2 at 0°C for 7h to give the 2'-deoxy-N6-methoxy-7-methyladenosine salt (14b), which was unstable and easily underwent glycosidic hydrolysis in H2O at 16-18°C to form N6-methoxy-7-methyladenine (15). On account of such instability, hydrogenolysis of 14b in H2O using hydrogen and Raney Ni catalyst failed to afford the desired nucleoside (5b). 2'-Deoxy-N6-methyladenosine (2b), 2'- deoxy-1-methyladenosine (3b), and 14b were found to undergo glycosidic hydrolysis in 0.1 N aqueous HCl at 25°C at rates of 7.92 x 10-2 min-1 (half-life 87.5 min), 5.02 x 10-3min-1 (half-life 138 min), and 2.31 x 10-2 min-1 (half-life 30.0 min), respectively, while the rate in the case of 5h was roughly estimated to be ca. 2 min-1 (half-life 0.35 min).
THE SYNTHESIS OF COMPOUNDS POSSESSING KINETIN ACTIVITY. THE USE OF A
LEONARD,FUJI
, p. 73 - 75 (2007/10/04)
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