51477-10-2

Basic information

• Product Name: (E)-1-(4-bromophenyl)-3-(4-methylphenyl)prop-2-en-1-one
• Synonyms: (E)-1-(4-bromophenyl)-3-(4-methylphenyl)prop-2-en-1-one
• CAS NO: 51477-10-2
• Molecular Formula: C₁₆H₁₃BrO
• Molecular Weight: 301.18
• Mol File: 51477-10-2.mol
• Article Data: 17

Chemical Properties

• Boiling Point: 416.4°C at 760 mmHg
• Flash Point: 70°C
• Appearance: /
• Density: 1.354g/cm³
• Vapor Pressure: 3.82E-07mmHg at 25°C
• Refractive Index: 1.635
• CAS DataBase Reference: (E)-1-(4-bromophenyl)-3-(4-methylphenyl)prop-2-en-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-1-(4-bromophenyl)-3-(4-methylphenyl)prop-2-en-1-one(51477-10-2)
• EPA Substance Registry System: (E)-1-(4-bromophenyl)-3-(4-methylphenyl)prop-2-en-1-one(51477-10-2)

Safety Data

• Hazardous Substances Data: 51477-10-2(Hazardous Substances Data)

Usage

Description

(E)-1-(4-bromophenyl)-3-(4-methylphenyl)prop-2-en-1-one is a chalcone derivative with a molecular formula C15H11BrO. It is a yellow solid with a melting point of around 94-97°C. (E)-1-(4-bromophenyl)-3-(4-methylphenyl)prop-2-en-1-one has potential biological activities and is being studied in the field of medicinal chemistry for its potential as a drug candidate. (E)-1-(4-bromophenyl)-3-(4-methylphenyl)prop-2-en-1-one's structure contains a conjugated system with a keto group, making it a candidate for synthetic anti-tumor and anti-inflammatory agents. Its chemical properties and potential biological activities make it an interesting subject for further research and development.

Uses

Used in Pharmaceutical Industry:
(E)-1-(4-bromophenyl)-3-(4-methylphenyl)prop-2-en-1-one is used as a potential drug candidate for its potential anti-tumor and anti-inflammatory properties. (E)-1-(4-bromophenyl)-3-(4-methylphenyl)prop-2-en-1-one's conjugated system with a keto group makes it a promising candidate for the development of synthetic agents in the pharmaceutical industry.
Used in Medicinal Chemistry Research:
(E)-1-(4-bromophenyl)-3-(4-methylphenyl)prop-2-en-1-one is used as a subject of study in medicinal chemistry to explore its potential biological activities and its application as a drug candidate. (E)-1-(4-bromophenyl)-3-(4-methylphenyl)prop-2-en-1-one's unique structure and properties make it an interesting area of research for the development of new therapeutic agents.
Used in Chemical Synthesis:
(E)-1-(4-bromophenyl)-3-(4-methylphenyl)prop-2-en-1-one is used as a starting material or intermediate in the synthesis of various chemical compounds, particularly those with potential applications in the pharmaceutical and medicinal chemistry fields. Its unique structure and reactivity make it a valuable component in the development of new synthetic pathways and products.

InChI:InChI=1/C16H13BrO/c1-12-2-4-13(5-3-12)6-11-16(18)14-7-9-15(17)10-8-14/h2-11H,1H3/b11-6+

Upstream product

• 104-87-0 4-methyl-benzaldehyde 
• 99-90-1 para-bromoacetophenone 
• 589-18-4 4-Methylbenzyl alcohol 
• 5391-88-8 1-(4-bromophenyl)ethanol 
• 1122-91-4 4-bromo-benzaldehyde 
• 122-00-9 para-methylacetophenone 
• 766-97-2 4-n-methylphenylacetylene 

Downstream Products

• 128883-53-4 6-(4-chlorophenyl)-2-oxo-4-(4-tolyl)-1,2,3,4-tetrahydro-3-pyridinecarboxamide 
• 115665-34-4 (4S,5R)-5-(4-Bromo-benzoyl)-1-(4-bromo-phenyl)-4-(4-methoxy-phenyl)-4,5-dihydro-1H-pyrazole-3-carboxylic acid ethyl ester 
• 127612-47-9 2-(4-bromobenzoyl)-1-(4-bromophenyl)-4-carboethoxy-4-cyano-3,5-di-(4-tolyl) cyclohexanol 
• 127394-68-7 6-(4-Bromo-phenyl)-2-ethoxy-4-p-tolyl-nicotinonitrile 
• 51477-14-6 (4-bromophenyl)-3-(p-tolyl)oxiran-2-yl-methanone 
• 1198089-03-0 C₃₅H₃₀BrFN₂ 
• 1251194-84-9 C₂₄H₂₀BrNO 
• 1234016-38-6 C₂₅H₂₀BrN₃S 
• 1226775-22-9 C₁₇H₁₆BrN₃S 
• 1332363-43-5 (3S,4S)-6-(4-bromophenyl)-3-(3-oxo-3-phenylpropyl)-4-p-tolyl-3,4-dihydro-2H-pyran-2-one 
• 1390626-93-3 2-(3-(4-bromophenyl)-3-oxo-1-p-tolylpropyl)-2H-indene-1,3-dione 
• 1390627-09-4 3-(4-bromophenyl)-5-p-tolyl-4,5-dihydroindeno[1,2-c][1,2]diazepin-6(1H)-one 
• 1390626-88-6 3-(4-bromophenyl)-5-p-tolyl-4,5-dihydroindeno[2,1-f][1,2]oxazepin-6-one 
• 1400673-93-9 5-bromo-2-(3-(4-bromophenyl)-5-p-tolyl-4,5-dihydro-1H-pyrazol-1-yl)pyrimidine 

Relevant articles and documents

Efficient base-free asymmetric one-pot synthesis of spiro[indoline-3,3′-pyrrolizin]-2-one derivatives catalyzed by chiral organocatalyst

A 1,3-dipolar cycloaddition reaction has been performed under organocatalytic conditions with high enantioselectivity by the utilization of bipyridine-based chiral quaternary ammonium bromide as an organocatalyst. Here, the reaction of 1,3-dipolar cycloaddition of azomethine ylide generated in situ from the decarboxylative condensation of α-amino acids and non-enolizable 1,2-diketones to the above dipolarophiles takes place.

Fabrication of Copper-based Silica-coated Magnetic Nanocatalyst for Efficient One-pot Synthesis of Chalcones via A3 Coupling of Aldehydes-Alkynes-Amines

In the present work, we have synthesized bioactive and pharmacologically important chalcone motifs by employing green and efficient silica-coated magnetically separable catalyst, Cu@DBM@ASMNPs. The highly proficient nanocatalyst proves its invincibility f

Design, synthesis, and biological evaluation of novel thienopyrimidine derivatives as PI3Kα inhibitors

Three series of novel thienopyrimidine derivatives 9a-l, 15a-l, and 18a-h were designed and synthesized, and their IC50 values against four cancer cell lines HepG-2, A549, PC-3, and MCF-7 were evaluated. Most compounds show moderate cytotoxicity against the tested cancer cell lines. The most promising compound 9a showed moderate activity with IC50 values of 12.32 ± 0.96, 11.30 ± 1.19, 14.69 ± 1.32, and 9.80 ± 0.93 μM, respectively. The inhibitory activities of compounds 9a and 15a against PI3Kα and mTOR kinase were further evaluated. Compound 9a exhibited PI3Kα kinase inhibitory activity with IC50 of 9.47 ± 0.63 μM. In addition, docking studies of compounds 9a and 15a were also investigated.