51483-87-5 Usage
Description
2,5-Pyrrolidinedicarboxylic acid, 1-(phenylMethyl)-, diMethyl ester, also known as 2,5-Dimethyl 1-benzylpyrrolidine-2,5-dicarboxylate, is a chemical compound with the molecular formula C14H17NO4. It is a derivative of pyrrolidinedicarboxylic acid, featuring a phenylmethyl group and two esterified carboxylic acid groups. 2,5-Pyrrolidinedicarboxylic acid, 1-(phenylMethyl)-, diMethyl ester is characterized by its potential applications in various fields due to its unique chemical structure.
Uses
Used in Pharmaceutical Industry:
2,5-Pyrrolidinedicarboxylic acid, 1-(phenylMethyl)-, diMethyl ester is used as a chemical intermediate for the preparation of beta-phospholactam. 2,5-Pyrrolidinedicarboxylic acid, 1-(phenylMethyl)-, diMethyl ester serves as a carbapenem transition state analog, which is crucial in the development of broad-spectrum inhibitors for metallo-beta-lactamases. Metallo-beta-lactamases are enzymes that can hydrolyze and inactivate a wide range of beta-lactam antibiotics, making them a significant concern in the field of antibiotic resistance. By targeting these enzymes, the compound contributes to the development of more effective antibiotics to combat resistant bacterial strains.
Check Digit Verification of cas no
The CAS Registry Mumber 51483-87-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,1,4,8 and 3 respectively; the second part has 2 digits, 8 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 51483-87:
(7*5)+(6*1)+(5*4)+(4*8)+(3*3)+(2*8)+(1*7)=125
125 % 10 = 5
So 51483-87-5 is a valid CAS Registry Number.
51483-87-5Relevant articles and documents
KRAS G12D INHIBITORS
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Paragraph 01377, (2021/03/05)
The present invention relates to compounds that inhibit KRas G12D. In particular, the present invention relates to compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor.
SPIRO-LACTAM AND BIS-SPIRO-LACTAM NMDA RECEPTOR MODULATORS AND USES THEREOF
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Page/Page column 35-36; 38-39; 40, (2018/03/28)
Disclosed are compounds having potency in the modulation of NMDA receptor activity. Such compounds can be used in the treatment of conditions such as depression and related disorders. Orally delivered formulations and other pharmaceutically acceptable delivery forms of the compounds, including intravenous formulations, are also disclosed.
Switching and Conformational Fixation of Amides Through Proximate Positive Charges
Bartuschat, Amelie L.,Wicht, Karina,Heinrich, Markus R.
, p. 10294 - 10298 (2015/09/01)
Tertiary amides, which usually occur as cis/trans mixtures, can be effectively shifted to the cis conformation by placing a positive charge in close proximity to the amide carbonyl. This effect was used to prepare cis-configured prolyl amides and to facilitate a strongly rotamer-dependent radical cyclization. Taking charge of conformation: Tertiary amides, which usually occur as cis/trans mixtures, can be effectively shifted to the cis conformation by placing a positive charge in close proximity to the amide carbonyl. This effect was used to prepare cis-configured prolyl amides and to facilitate a strongly rotamer-dependent radical cyclization.
