51600-12-5

Basic information

• Product Name: Uridine, 5'-O-[(4-methoxyphenyl)diphenylmethyl]-
• CAS NO: 51600-12-5
• Molecular Formula: C29H28N2O7
• Molecular Weight: 516.551
• Mol File: 51600-12-5.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: Uridine, 5'-O-[(4-methoxyphenyl)diphenylmethyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Uridine, 5'-O-[(4-methoxyphenyl)diphenylmethyl]-(51600-12-5)
• EPA Substance Registry System: Uridine, 5'-O-[(4-methoxyphenyl)diphenylmethyl]-(51600-12-5)

Safety Data

• Hazardous Substances Data: 51600-12-5(Hazardous Substances Data)

Upstream product

• 66-22-8 uracil 
• 1333311-80-0 benzyl p-monomethoxytrityl ether 
• 58-96-8 uridine 
• 14470-28-1 mono-4-methoxytrityl chloride 
• 112123-79-2 5'-O-(monomethoxytrityl)uridine 2':3'-carbonate(cyclic) 

Downstream Products

• 185761-17-5 1-{(2R,3R,4S,5R)-3,4-Dihydroxy-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-2-yl}-3-(4-methoxy-benzoyl)-1H-pyrimidine-2,4-dione 
• 1609582-81-1 N-benzyl-2’,3’-O-diacetyl-5-(2-ethoxy-1,1-difluoro-2-oxoethyl)-5’-O-(p-methoxy-α,α-diphenylbenzyl)uridine 
• 1609582-94-6 N-benzyl-2’,3’-O-diacetyl-5’-O-(p-methoxy-α,α-diphenylbenzyl)uridine 
• 87875-12-5 5'-O-(monomethoxytrityl)-2',3'-bis-O-(acetyl)uridine 
• 38642-15-8 2'-O-Trityluridine 
• 1313496-56-8 5'-O-monomethoxytrityl-3'-O-propargyluridine 
• 135944-17-1 5'-O-(4-monomethoxytrityl)-2'-O-methyl-6-N-(9-fluorenylmethoxycarbonyl)adenylyl-(3'->5')-2',3'-di-O-levulinoyluridine O-(methyl phosphate) 
• 185761-18-6 N³-(4-methoxybenzoyl)-2'-O-methyl-5'-O-(monomethoxytrityl)uridine 
• 119932-70-6 1-<1-tert-butyldimethylsilyloxy-5-(p-monomethoxytrityloxy)-4(S)-hydroxymethyl-3-oxa-2(R)-pentyl>uracil 
• 119932-71-7 1-<4(R)-tert-butyldimethylsilyloxymethyl-5-(p-monomethoxytrityloxy)-1-hydroxy-3-oxa-2(R)-pentyl>uracil 
• 58-96-8 uridine 
• 537041-04-6 (R)-2-[(R)-1-(2,4-Dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-oxo-ethoxy]-3-[(4-methoxy-phenyl)-diphenyl-methoxy]-propionaldehyde 

Relevant articles and documents

Direct One-Pot Synthesis of Nucleosides from Unprotected or 5-O-Monoprotected d -Ribose

New, improved methods to access nucleosides are of general interest not only to organic chemists but to the greater scientific community as a whole due their key implications in life and disease. Current synthetic methods involve multistep procedures employing protected sugars in the glycosylation of nucleobases. Using modified Mitsunobu conditions, we report on the first direct glycosylation of purine and pyrimidine nucleobases with unprotected d-ribose to provide β-pyranosyl nucleosides and a one-pot strategy to yield β-furanosides from the heterocycle and 5-O-monoprotected d-ribose.

An efficient and selective method for the preparation of triphenylmethyl ethers of alcohols and nucleosides

A very simple and efficient method is described for the protection of alcohols and nucleosides with benzyl monomethoxytrityl and benzyl dimethoxytrityl ethers in the presence of diethylazodicarboxylate and a catalytic amount of ceric triflate. High selectivity was observed for the tritylation of 5'-OH function of nucleosides.

Nucleosides. Part LI. The 2-(4-Nitrophenyl)ethoxycarbonyl (npeoc) and 2-(2,4-Dinitrophenyl)ethoxycarbonyl (dnpeoc) Groups for Protection of Hydroxy Functions in Ribonucleosides and 2'-Deoxyribonucleosides

The common 2'-deoxypyrimidine and -purine nucleosides, thymidine (4), O4-thymidine (17), 2'-deoxy-N4-cytidine (26), 2'-deoxy-N6-adenosine (39), and 2'-deoxy-N2--O6-guanosine (52) were further protected by the 2-(4-nitrophenyl)ethoxycarbonyl (npeoc) and the 2-(2,4-dinitrophenyl)ethoxycarbonyl (dnpeoc) group at the OH functions of the sugar moiety to form new partially and fully blocked intermediates for nucleoside and nucleotide syntheses.The corresponding 5'-O-monomethoxytrityl derivatives 5, 18, 30, 40, and 56 were also used as starting material to synthesize some other intermediates which were not obtained by direct acylations.In the ribonucleoside series, the 5'-O-monomethoxytrityl derivatives 14, 36, 49, and 63 reacted with 2-(4-nitrophenyl)ethyl chloroformate (1) to the corresponding 2',3'-bis-carbonates 15, 37, 50, and 64 which were either detritylated to 16, 38, 51, and 65, respectively, or converted by 1,8-diazabicycloundec-7-ene (DBU) treatment to the 2',3'-cyclic carbonates 66-69.The newly synthesized compounds were characterized by elemental analyses and UV and 1H-NMR spectra.