51619-55-7

Basic information

• Product Name: 1-(1-HEXYL)-PIPERAZINE
• Synonyms: 1-N-HEXYL-PIPERAZINE;1-(1-HEXYL)-PIPERAZINE;1-HEXYLPIPERAZINE;RARECHEM AH CK 0110;Piperazine, 1-hexyl- (9CI);1-Hexylpiperazine 97%;1-(1-HEXYL)-PIPERAZINE >98%;1-(Hex-1-yl)piperazine 97%
• CAS NO: 51619-55-7
• Molecular Formula: C₁₀H₂₂N₂
• Molecular Weight: 170.3
• EINECS: 625-179-8
• Product Categories: PIPERIDINE;Piperidines, Piperidones, Piperazines;Building Blocks;Heterocyclic Building Blocks;Piperazines
• Mol File: 51619-55-7.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 98-103°C 10mm
• Flash Point: 81.4 °C
• Appearance: /
• Density: 0.877 g/mL at 20 °C(lit.)
• Vapor Pressure: 0.0412mmHg at 25°C
• Refractive Index: n20/D 1.466
• PKA: 9.32±0.10(Predicted)
• BRN: 7853961
• CAS DataBase Reference: 1-(1-HEXYL)-PIPERAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(1-HEXYL)-PIPERAZINE(51619-55-7)
• EPA Substance Registry System: 1-(1-HEXYL)-PIPERAZINE(51619-55-7)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26
• WGK Germany: 3
• F: 10-34
• HazardClass: IRRITANT
• Hazardous Substances Data: 51619-55-7(Hazardous Substances Data)

Usage

General Description

1-(1-hexyl)-piperazine is a chemical compound with the molecular formula C11H24N2. It is a piperazine derivative, which is a class of organic compounds that contain a six-membered heterocyclic ring with two nitrogen atoms. 1-(1-HEXYL)-PIPERAZINE is often used in the synthesis of pharmaceuticals and is known to have psychoactive effects. Its structure consists of a piperazine ring with a hexyl group attached to one of the nitrogen atoms. Due to its psychoactive properties, it has been studied for its potential use in the treatment of certain mental health disorders. Additionally, it is also used as an intermediate in the production of other organic compounds.

InChI:InChI=1/C10H22N2/c1-2-3-4-5-8-12-9-6-11-7-10-12/h11H,2-10H2,1H3

Upstream product

• 110-89-4 piperidine 
• 109-67-1 1-penten 
• 201230-82-2 carbon monoxide 
• 110-85-0 piperazine 
• 111-25-1 1-bromo-hexane 

Downstream Products

• 1027237-89-3 Acetic acid 4-(4-hexyl-piperazine-1-carbonyl)-phenyl ester 
• 344448-95-9 (4-Hexyl-piperazin-1-yl)-(4-hydroxy-phenyl)-methanone 
• 1333141-80-2 C₂₃H₃₆N₆O₂S 
• 339074-49-6 N'-(4-formylphenyl)-N-hexylpiperazine 
• 42992-87-0 N-hexyl-N'-benzylpiperazine 

Relevant articles and documents

Novel Naphthalimide Aminothiazoles as Potential Multitargeting Antimicrobial Agents

A series of novel naphthalimide aminothiazoles were developed for the first time and evaluated for their antimicrobial activity. Some prepared compounds possessed good inhibitory activity against the tested bacteria and fungi. Noticeably, the piperazine derivative 4d displayed superior antibacterial activity against MRSA and Escherichia coli with MIC values of 4 and 8 μg/mL, respectively, to reference drugs. The most active compound 4d showed low toxicity against mammalian cells with no obvious triggering of the development of bacterial resistance, and it also possessed rapid bactericidal efficacy and efficient membrane permeability. Preliminarily investigations revealed that compound 4d could not only bind with gyrase-DNA complex through hydrogen bonds but could effectively intercalate into MRSA DNA to form 4d-DNA supramolecular complex, which might be responsible for the powerful bioactivity. Further transportation behavior evaluation indicated that molecule 4d could be effectively stored and carried by human serum albumin, and the hydrophobic interactions and hydrogen bonds played important roles in the binding process.