51656-70-3Relevant articles and documents
MACROCYCLIC SULFONYLAMIDE DERIVATIVES USEFUL AS NLRP3 INHIBITORS
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Page/Page column 179; 247, (2021/02/26)
The present invention relates to macrocyclic compounds, such as macrocyclic sulfonyl amides. The present invention further relates to associated salts, solvates, prodrugs and pharmaceutical compositions, and to the use of such compounds in the treatment and prevention of medical disorders and diseases, most especially by NLRP3 inhibition.
DIFLUOROCYCLOHEXYL DERIVATIVES AS IL-17 MODULATORS
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Page/Page column 60, (2021/10/15)
A series of substituted 4,4-difluorocyclohexyl derivatives as defined herein, being potent modulators of human IL-17 activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including inflammatory and autoimmune disorders.
FUSED IMIDAZOLE DERIVATIVES AS IL-17 MODULATORS
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Page/Page column 66, (2021/01/23)
A series of substituted fused bicyclic imidazole derivatives of formula (I), including benzimidazole derivatives and analogues thereof, being potent modulators of human IL-17 activity, are accordingly of benefit in the treatment and/or prevention of various human ailments including inflammatory and autoimmune disorders, wherein i. a. A represents C-R1 or N; B represents C-R2 or N; D represents C-R3 or N; E represents C-R4 or N; Z represents -CH(R5)N(H)CH2R6, -CH(R5)N(H)S(O)2R6, -C(=CR5aR5b)N(H)C(O)R6, -CH(R5)R7, -CH(R5)N(H)R7 or -CH(R5)C(O)N(H)R7; R0 represents hydrogen or C1-6 alkyl.