51677-09-9

Basic information

• Product Name: 5-PHENYL-ISOXAZOLE-3-CARBOXYLIC ACID METHYL ESTER
• Synonyms: ART-CHEM-BB B024670;METHYL 5-PHENYLISOXAZOLE-3-CARBOXYLATE;METHYL 5-PHENYL-3-ISOXAZOLECARBOXYLATE;AKOS B024670;AKOS BBS-00002559;5-PHENYL-ISOXAZOLE-3-CARBOXYLIC ACID METHYL ESTER;TIMTEC-BB SBB009684;5-Phenyl-3-isoxazolecarboxylic acid methyl ester
• CAS NO: 51677-09-9
• Molecular Formula: C₁₁H₉NO₃
• Molecular Weight: 203.19
• Mol File: 51677-09-9.mol
• Article Data: 21

Chemical Properties

• Melting Point: 81°C
• Boiling Point: 370.2°Cat760mmHg
• Flash Point: 177.7°C
• Appearance: /
• Density: 1.204g/cm³
• Vapor Pressure: 1.13E-05mmHg at 25°C
• Refractive Index: 1.541
• Storage Temp.: 2-8°C
• PKA: -6.43±0.28(Predicted)
• CAS DataBase Reference: 5-PHENYL-ISOXAZOLE-3-CARBOXYLIC ACID METHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 5-PHENYL-ISOXAZOLE-3-CARBOXYLIC ACID METHYL ESTER(51677-09-9)
• EPA Substance Registry System: 5-PHENYL-ISOXAZOLE-3-CARBOXYLIC ACID METHYL ESTER(51677-09-9)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 51677-09-9(Hazardous Substances Data)

Usage

Uses

Methyl 5-Phenylisoxazole-3-carboxylate is a useful reagent for reactions with isoxazoles.

InChI:InChI=1/C11H9NO3/c1-14-11(13)9-7-10(15-12-9)8-5-3-2-4-6-8/h2-7H,1H3

Upstream product

• 41158-32-1 methyl 4-oxo-4-phenylbut-2-ynoate 
• 2483-57-0 methyl 2-nitroacetate 
• 536-74-3 phenylacetylene 
• 5437-67-2 dimethyl 2-nitromalonate 
• 20577-73-5 methyl 4-phenyl-2,4-dioxobutanoate 
• 98-86-2 acetophenone 
• 14441-90-8 5-phenyl-3-isoxazolecarboxylic acid 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 2687-43-6 O-benzylhydoxylamine hydrochloride 
• 30673-27-9 methyl chlorooximidoacetate 
• 67-56-1 methanol 
• 588-72-7 [(E)-2-bromoethenyl]benzene 

Downstream Products

• 169271-97-0 N,N-dimethyl-5-phenylisoxazole-3-carboxamide 
• 59985-82-9 5-phenylisoxazole-3-carbaldehyde 
• 23088-52-0 5-phenylisoxazole-3-carboxamide 
• 14442-24-1 5-phenylisoxazole-3-carbonitrile 
• 179055-62-0 Cycloheptyl-(5-phenyl-isoxazol-3-ylmethyl)-amine 
• 1307815-53-7 C₂₁H₁₆N₂O₃ 
• 3672-49-9 phenyl(5-phenyl-1,2-oxazol-3-yl)methanone 
• 76973-05-2 diphenyl(5-phenylisoxazol-3-yl)methanol 
• 1384436-00-3 1-(5-phenylisoxazol-3-yl)hept-2-yn-1-one 
• 14441-90-8 5-phenyl-3-isoxazolecarboxylic acid 
• 101291-06-9 N⁽³⁾,5-diphenylizoxazole-3-carboxamide 
• 1427310-10-8 2-(4-hydroxy-1,2,5-oxadiazol-3-yl)-1-phenylethanone 

Relevant articles and documents

Mechanochemistry Enabled Construction of Isoxazole Skeleton via CuO Nanoparticles Catalyzed Intermolecular Dehydrohalogenative Annulation

A dehydrohalogenative approach for isoxazole annulation by partnering β-vinyl halides and α-nitrocarbonyls under mechanochemical setting was accomplished. This chemistry is operative under the cooperative catalysis of cupric oxide nanoparticles (50 nm) a

Novel isoxazole derivatives as potential antiparkinson agents: synthesis, evaluation of monoamine oxidase inhibitory activity and docking studies

Selective monoamine oxidase B inhibitors are potential drug candidates for the treatment of Parkinson’s disease. A series of phenyl substituted isoxazole carbohydrazides was designed by structural modification of isocarboxazid, a nonselective MAO inhibito

Structure-Based Design of MptpB Inhibitors That Reduce Multidrug-Resistant Mycobacterium tuberculosis Survival and Infection Burden in Vivo

Mycobacterium tuberculosis protein-tyrosine-phosphatase B (MptpB) is a secreted virulence factor that subverts antimicrobial activity in the host. We report here the structure-based design of selective MptpB inhibitors that reduce survival of multidrug-resistant tuberculosis strains in macrophages and enhance killing efficacy by first-line antibiotics. Monotherapy with an orally bioavailable MptpB inhibitor reduces infection burden in acute and chronic guinea pig models and improves the overall pathology. Our findings provide a new paradigm for tuberculosis treatment.