51699-90-2Relevant articles and documents
Polynuclear Cu4L4 Copper(II) Aminyl Radical Coordination Complexes
Bonanno, Nico M.,Lough, Alan J.,Lemaire, Martin T.
, p. 4837 - 4840 (2018)
We describe the structural features and magnetic properties of two polynuclear copper(II) complexes containing a redox-active ligand. These neutral complexes each bear the formula RL4Cu4 (R = tBu, Me) with the ligand in a dianion-aminyl radical oxidation state. X-ray data and density functional theory calculations support an aminyl-type radical character in these complexes, making these the first polynuclear metal aminyl radical complexes.
Iodothyronine Deiodinase Mimics. Deiodination of o,o'-Diiodophenols by Selenium and Tellurium Reagents
Vasil'ev, Andrei A.,Engman, Lars
, p. 3911 - 3917 (2007/10/03)
To better understand, and in the extension mimic, the action of the three selenium-containing iodothyronine deiodinases, o,o'-diiodophenols were reacted under acidic conditions with sodium hydrogen telluride, benzenetellurol, sodium hydrogen selenide, or benzeneselenol and under basic conditions with the corresponding deprotonated reagents. Sodium hydrogen telluride was found to selectively remove one iodine from a variety of 4-substituted o,o'-diiodophenols, including a protected form of thyroxine (T4). Thus, it mimics the D1 variety of the iodothyronine deiodinases. Sodium telluride was a more reactive deiodinating agent toward o,o'-diiodophenols, often causing removal of both halogens. Benzenetellurol and sodium benzenetellurolate sometimes showed useful selectivity for monodeiodination. However, the products were often contaminated by small amounts of organotellurium compounds. Sodium hydrogen selenide, sodium selenide, benzeneselenol, and sodium benzeneselenolate were essentially unreactive toward o,o'-diiodophenols. To gain more insight into thyroxine inner-ring deiodination, substituted 2,6-diiodophenyl methyl ethers were treated with some of the chalcogen reagents. Reactivity and selectivity for monodeiodination varied considerably depending on the substituents attached to the aromatic nucleus. In general, it was possible to find reagents that could bring about the selective mono- or dideiodination of these substrates.
