51708-72-6Relevant articles and documents
CYCLIC AMIDE DERIVATIVES, AND THEIR PRODUCTION AND USE AS ANTITHROMBOTIC AGENTS
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Page/Page column 108-109, (2010/02/14)
The present invention provides a cyclic amide derivative useful as a drug for treating thrombosis, which is represented by the formula (I): wherein R1 represents an optionally substituted cyclic hydrocarbon group or an optionally substituted heterocyclic group, W represents a bond or an optionally substituted divalent chain hydrocarbon group, a represents 0, 1, or 2, X1 represents an optionally substituted lower alkylene or an optionally substituted lower alkenylene, Y1 represents -C(O)-, -S(O)- or -S(O)2-, A represents a piperazine ring which may be further substituted or a piperidine ring which may be further substituted, X2 represents a bond or an optionally substituted lower alkylene, Y2 represents -C(O)-, -S(O)-, -S(O)2- or -C(=NR7)-, X3 represents an optionally substituted C1-4 alkylene or an optionally substituted C2-4 alkenylene, Z3 represents -N(R4)-, -O- or a bond, Z1 represents -C(R2)(R2')-, -N(R2)-, etc., and Z2 represents -C(R3)(R3')-, -N(R3)-, etc., or a salt thereof.
Cyclopropane Derivatives, 3. - (1-Alkylcyclopropyl)ketones by Acylation of α-Substituted γ-Lactones
Boehrer, Gerald,Boehrer, Petra,Knorr, Rudolf
, p. 2167 - 2172 (2007/10/02)
The 2-acylation of 2-substituted 4-butanolides 2 is moderately sensitive to steric crowding, whereas the subsequent ring-opening of 2-acyl-2-alkyl-4-butanolides 4, 11 to give γ-chloroketones 6, 12 by chlorine-transferring acid derivatives becomes difficult with bigger lactone substituents.Similar observations pertain to the preparation of γ-chlorobutanoyl chlorides 10 from 2-alkyl-4-butanolides 2.The proper choice of the starting 4-butanolides (2a, b or 14 but not 2c) provides for an indirect coupling of two different lactones to γ,γ'-dichloro ketones 12.Dicyclopropyl ketones 13 with variable patterns of substitution may thus be prepared from 4-butanolides in a direct manner with global yields exceeding 50percent and without purification of intermediate products (except for acid chlorides like 10).
Chlorination of Carboxylic Acid Derivatives. VIII. Liquid Phase Chlorination of the Aliphatic C5-Carboxylic Acids and Their Chlorides, Methyl Esters and Chloromethyl Esters with Chlorine
Kornonen, Ilpo O. O.
, p. 467 - 474 (2007/10/02)
The chlorination of pentanoic, 3-methylbutanoic, 2-methylbutanoic and 2,2-dimethylpropanoic acids and their derivatives with chlorine in the liquid phase have been investigated.The monochloro products formed were determined by gas-liquid chromatography (GLC) and gas-liquid chromatography-mass spectrometry (GLC-MS) as their esters through the comparison with authentic samples.The deactivation of position 2 decreases in the order COCl > CO2H > CO2CH2Cl > CO2CH3, the effect of the COCl-group in pentanoic acid derivatives being 4.3 times stronger than that of the CO2CH3-group.The deactivation is smallest in 2-methylbutanoic acid derivatives owing to the electron-donating methyl group.The EI mass spectra of the methyl and chloromethyl esters have been studied in detail.