5172-06-5

Basic information

• Product Name: 1-Chloro-2,3,4,6-tetrafluorobenzene
• Synonyms: 1-Chloro-2,3,4,6-tetrafluorobenzene;1-Chloro-3H-perfluorobenzene;2-Chloro-1,3,4,5-tetrafluorobenzene;2-Chloro-1,3,4,5-tetrafluorobenzene, 1-Chloro-3H-tetrafluorobenzene;3-Chloro-1H-tetrafluorobenzene;2,3,4,6-Tetrafluorochlorobenzene
• CAS NO: 5172-06-5
• Molecular Formula: C₆HClF₄
• Molecular Weight: 184.5187528
• Mol File: 5172-06-5.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 123-123.5℃
• Flash Point: 31.3°C
• Appearance: /
• Density: 1.56g/cm³
• Vapor Pressure: 13mmHg at 25°C
• Refractive Index: 1.4410 (589.3 nm 20℃)
• CAS DataBase Reference: 1-Chloro-2,3,4,6-tetrafluorobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Chloro-2,3,4,6-tetrafluorobenzene(5172-06-5)
• EPA Substance Registry System: 1-Chloro-2,3,4,6-tetrafluorobenzene(5172-06-5)

Safety Data

• Hazardous Substances Data: 5172-06-5(Hazardous Substances Data)

Usage

General Description

1-Chloro-2,3,4,6-tetrafluorobenzene is a chemical compound with the molecular formula C6H2ClF4. It is a chlorinated derivative of tetrafluorobenzene and is used as a building block in the synthesis of various organic compounds. This colorless liquid is mainly used as an intermediate for pharmaceuticals, agrochemicals, and dyes. It is also used as an intermediate for the production of specialty polymers and as a solvent in chemical reactions. Additionally, it is used in the production of fine chemicals and as a research chemical in laboratories. However, it is important to handle this chemical with care and follow proper safety protocols due to its potential health hazards.

InChI:InChI=1/C6HClF4/c7-4-2(8)1-3(9)5(10)6(4)11/h1H

Upstream product

• 1559-86-0 2-bromo-1,3,4,5-tetrafluorobenzene 
• 1198-61-4 1,3-dichloro-2,4,5,6-tetrafluorobenzene 
• 5360-81-6 3-chloro-2,4,5,6-tetrafluorobenzoic acid 
• 75-77-4 chloro-trimethyl-silane 
• 13702-80-2 3-Chlor-2,4,5,6-tetrafluor-benzoesaeurefluorid 
• 1825-23-6 pentachlorobenzoyl chloride 
• 344-07-0 1-chloro-2,3,4,5,6-pentafluorobenzene 

Downstream Products

• 13332-11-1 1-Chlor-4-methoxy-2,3,6-trifluorbenzol 
• 13555-12-9 1-Chlor-2-methoxy-3,4,6-trifluorbenzol 
• 13332-02-0 1-Chlor-4-dimethylamino-2.3.6-trifluor-benzol 
• 13332-01-9 1-Chlor-2-dimethylamino-3.4.6-trifluor-benzol 
• 58825-33-5 3-Chlor-2,4,5,6-tetrafluorphenyl-bispentafluorphenylmethan 
• 1258626-39-9 3,3-dichloro-2,2',4,4',5,5',6,6'-octafluorodiphenyl disulfide 
• 1258626-43-5 3-chloro-2,4,5,6-tetrafluorophenylsulfenyl chloride 
• 1258866-40-8 1,5-bis(3-chloro-2,4,5,6-tetrafluorophenyl)-2,4-diaza-1,3,5-trithia-2,3-pentadiene 
• 1258866-41-9 1,5-bis(3-chloro-2,4,5,6-tetrafluorophenyl)-2,4-diaza-1,5-diselena-3-thia-2,3-pentadiene 
• 1258626-44-6 3,3'-dichloro-2,2',4,4',5,5',6,6'-octafluorodiphenyl diselenide 
• 1258626-46-8 3-chloro-2,4,5,6-tetrafluorophenylselenenyl chloride 

Relevant articles and documents

Transition-Metal-Free Catalytic Hydrodefluorination of Polyfluoroarenes by Concerted Nucleophilic Aromatic Substitution with a Hydrosilicate

A transition-metal-free catalytic hydrodefluorination (HDF) reaction of polyfluoroarenes is described. The reaction involves direct hydride transfer from a hydrosilicate as the key intermediate, which is generated from a hydrosilane and a fluoride salt. The eliminated fluoride regenerates the hydrosilicate to complete the catalytic cycle. Dispersion-corrected DFT calculations indicated that the HDF reaction proceeds through a concerted nucleophilic aromatic substitution (CSNAr) process.

Reactions of polyfluoroaromatic compounds with electrophilic agents in the presence of tris(dialkylamino)phosphine: 6. * Reactions of halogenotetrafluorobenzenes RC6F4X (X = Cl, Br, or I) with chlorotrimethylsilane

The rate of replacement of the halogen atom in isomers of RC6F4X (X = Cl, Br, or I) by the SiMe3 group under the action of Me3SiCl and P(NEt2)3 depends on the nature and the mutual arrangement of the substituents X and R. In addition to silyldehalogenation, compounds C6HF4X (X = Br or I) undergo silyldeprotonation and reduction to tetrafluorobenzenes.