51753-57-2

Basic information

• Product Name: 7-Bromo-5-(2-chlorophenyl)-1,3-dihydro-2H-1,4-Benzodiazepin-2-one
• Synonyms: PHENAZEPAM;2H-1,4-BENZODIAZEPIN-2-ONE, 7-BROMO-5-(2-CHLOROPHENYL)-1,3-DIHYDRO-;7-BROMO-5-[O-CHLOROPHENYL]-1,3-DIHYDRO-2H-1,4-BENZODIAZEPIN-2-ONE;7-BROMO-5-(2-CHLORO-PHENYL)-1,3-DIHYDRO-2H-1,4-BENZODIAZEPIN-2-ONE;5-(2-Chlorophenyl)-7-bromo-1,4-benzodiazepin-2-one;IFLAB-BB F0133-0017;1,3-dihydro-7-bromo-5-(2-chlorophenyl)-2h-4-benzodiazepin-2-one;7-bromo-5-(2-chlorophenyl)-1,3-dihydro-2h-4-benzodiazepin-2-one
• CAS NO: 51753-57-2
• Molecular Formula: C₁₅H₁₀BrClN₂O
• Molecular Weight: 349.61
• EINECS: 200-835-2
• Product Categories: Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Psychopathic Drugs;Phenazepam ada@tuskwei.com whatsapp;8618031153937
• Mol File: 51753-57-2.mol
• Article Data: 3

Chemical Properties

• Melting Point: 214-224°C
• Boiling Point: 493 °C at 760 mmHg
• Flash Point: 2℃
• Appearance: White or off-white crystalline powder
• Density: 1.61 g/cm³
• Refractive Index: 1.691
• Storage Temp.: Controlled Substance, -20°C Freezer
• PKA: 11.58±0.70(Predicted)
• CAS DataBase Reference: 7-Bromo-5-(2-chlorophenyl)-1,3-dihydro-2H-1,4-Benzodiazepin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 7-Bromo-5-(2-chlorophenyl)-1,3-dihydro-2H-1,4-Benzodiazepin-2-one(51753-57-2)
• EPA Substance Registry System: 7-Bromo-5-(2-chlorophenyl)-1,3-dihydro-2H-1,4-Benzodiazepin-2-one(51753-57-2)

Safety Data

• Hazard Codes: F,Xn
• Statements: 11-20/21/22-36
• Safety Statements: 16-36/37
• RIDADR: UN 1648 3 / PGII
• WGK Germany: 2
• Hazardous Substances Data: 51753-57-2(Hazardous Substances Data)

Usage

Description

7-Bromo-5-(2-chlorophenyl)-1,3-dihydro-2H-1,4-Benzodiazepin-2-one, also known as Phenazepam, is a benzodiazepine drug with sedative and hypnotic properties. It is a pale yellow solid and has been used in the treatment of neurological disorders, as well as for its anxiolytic, anticonvulsant, and muscle relaxant effects. Although not used therapeutically in the US, it can be purchased for research purposes and has been reported to be abused in some regions.

Uses

Used in Pharmaceutical Industry:
7-Bromo-5-(2-chlorophenyl)-1,3-dihydro-2H-1,4-Benzodiazepin-2-one is used as a treatment for neurological disorders such as epilepsy, alcohol withdrawal, and insomnia. It helps in managing the symptoms and providing relief to the patients.
Used in Preoperative Medicine:
7-Bromo-5-(2-chlorophenyl)-1,3-dihydro-2H-1,4-Benzodiazepin-2-one is used as a premedication before surgery. It augments the effects of anesthetics and helps in reducing anxiety in patients, ensuring a smoother surgical process.
Used in Research and Forensic Applications:
As a certified reference material, 7-Bromo-5-(2-chlorophenyl)-1,3-dihydro-2H-1,4-Benzodiazepin-2-one is utilized in research and forensic applications to study its properties and detect its presence in illicit tablets, contributing to the development of new drugs and the fight against drug abuse.

Safety Profile

Moderately toxic by ingestion and intraperitoneal routes. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of Clí, Brí, and NOx.

InChI:InChI=1/C15H8BrClN2O/c16-9-5-6-13-11(7-9)15(18-8-14(20)19-13)10-3-1-2-4-12(10)17/h1-8H

Upstream product

• 16437-59-5 phthalic acid hydrazide 
• 87213-48-7 5-bromo-2'-chloro-2-(phthalimidoacetamido)benzophenone 
• 60773-49-1 (2-amino-5-bromophenyl)(2-chlorophenyl)methanone 
• 598-21-0 2-Bromoacetyl bromide 

Downstream Products

• 126494-59-5 7-bromo-1-tert-butyloxycarbonylmethyl-5-(2-chlorophenyl)-1,2-dihydro-3H-1,4-benzodiazepin-2-one 
• 87213-49-8 7-bromo-5-(2-chlorophenyl)-1,3-dihydro-1,4-benzodiazepin-2-thione 
• 60773-49-1 (2-amino-5-bromophenyl)(2-chlorophenyl)methanone 
• 70030-11-4 3-hydroxy-7-bromo-5-(2'-chlorophenyl)-1,2-dihydro-3H-1,4-benzodiazepin-2-one 
• 74077-27-3 7-Bromo-5-(2-chloro-3-hydroxy-phenyl)-1,3-dihydro-benzo[e][1,4]diazepin-2-one 
• 74077-28-4 7-Bromo-5-(2-chloro-phenyl)-9-hydroxy-1,3-dihydro-benzo[e][1,4]diazepin-2-one 
• 74077-25-1 7-Bromo-5-(2-chloro-6-hydroxy-phenyl)-1,3-dihydro-benzo[e][1,4]diazepin-2-one 
• 74077-26-2 7-Bromo-5-(2-chloro-4-hydroxy-5-methoxy-phenyl)-1,3-dihydro-benzo[e][1,4]diazepin-2-one 
• 87213-50-1 8-bromo-5-(2-chlorophenyl)-1-methyl-4H-s-triazolo<4,3-a>-1,4-benzodiazepine 
• 87245-49-6 8-bromo-5-(2-chlorophenyl)-1-(methylthiomethyl)-4H-s-triazolo<4,3-a>-1,4-benzodiazepine 
• 130788-49-7 7-bromo-3-hydroxy-1-carboxymethyl-5-(o-chlorophenyl)-1,2-dihydro-3H-1,4-benzdiazepin-2-one 
• 130788-50-0 7-bromo-1-tert-butyloxycarbonylmethyl-3-hydroxy-5-(o-chlorophenyl)-1,2-dihydro-3H-1,4-benzdiazepin-2-one 
• 130788-51-1 3-acetoxy-7-bromo-1-tert-butyloxycarbonylmethyl-5-(o-chlorophenyl)-1,2-dihydro-3H-1,4-benzdiazepin-2-one 
• 126494-60-8 7-bromo-1-carboxymethyl-5-(2-chlorophenyl)-1,2-dihydro-3H-1,4-benzodiazepin-2-one 

Relevant articles and documents

Stereospecific anxiolytic and anticonvulsant agents with reduced muscle-relaxant, sedative-hypnotic and ataxic effects

The present invention provides compositions and methods of using stereospecific benzodiazepine derivatives, their salts and prodrugs for the treatment of anxiolytic or convulsant disorders having the side effects of reduced alcohol craving in human alcoholics and a concomitant reduced sedative, hypnotic, muscle relaxant and ataxic side-effects. The invention further provides pharmaceutical compositions for treatment of anxiolytic and convulsant disorders in subjects in need thereof, comprising a compound, prodrug or a salt having a chemical structure represented by any one of Formula I-XXI and a pharmaceutically-acceptable carrier.

Synthesis of two 1-substituted 8-bromo-6-(2-chlorophenyl)-4H-s-triazolo[4,3-a]-1,4-benzodiazepines

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