51761-45-6

Basic information

• Product Name: Methanesulfonic acid (diethoxy-phosphoryl)-phenyl-methyl ester
• CAS NO: 51761-45-6
• Molecular Weight: 322.319
• Mol File: 51761-45-6.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Methanesulfonic acid (diethoxy-phosphoryl)-phenyl-methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Methanesulfonic acid (diethoxy-phosphoryl)-phenyl-methyl ester(51761-45-6)
• EPA Substance Registry System: Methanesulfonic acid (diethoxy-phosphoryl)-phenyl-methyl ester(51761-45-6)

Safety Data

• Hazardous Substances Data: 51761-45-6(Hazardous Substances Data)

Upstream product

• 1663-55-4 diethyl [hydroxy(phenyl)methyl]phosphonate 
• 124-63-0 methanesulfonyl chloride 
• 3277-27-8 diethyl benzoylphosphonate 
• 85185-11-1 (Hydroxy-phenyl-methyl)-phosphonic acid diethyl ester 
• 100-52-7 benzaldehyde 
• 31675-43-1 diethyl 1-phenyl-1-(trimethylsiloxy)methanephosphonate 
• 762-04-9 Diethyl phosphonate 
• 51761-34-3 C₅H₁₃O₅PS 

Downstream Products

• 13676-09-0 (ethoxy-phenyl-methyl)phosphonic acid diethyl ester 
• 16153-59-6 (diethoxyphosphoryl)(phenyl)methyl acetate 
• 177720-01-3 diethyl 1-hydroazinobenzylphosphonate 
• 85166-84-3 Trifluoro-acetic acid (diethoxy-phosphoryl)-phenyl-methyl ester 
• 85166-83-2 [Phenyl-(2,2,2-trifluoro-ethoxy)-methyl]-phosphonic acid diethyl ester 

Relevant articles and documents

Stereoselective synthesis and biological activities of diethyl (E)-{[4-cyano-5-[[(disubstitutedamino)methylene]amino]-3-(methylthio) -1H-pyrazol-1-yl]substituited phenylmethyl}phosphonates

(Chemical Equation Presented) Diethyl {[5-amino-4-cyano-3-(methylthio)-1H- pyrazol-1-yl]substitutedphenylmethyl}phosphonates 3 were efficiently synthesized via the condensation of [(1-hydrazino)substitutedphenylmethyl]phosphonates 1 with 2-[bis(methylthio

Studies of organophosphorus compounds 91: A novel synthesis of 1-hydrazinoalkylphosphonic acids and derivatives thereof

Condensation of diethyl phosphite with aldehydes followed by subsequent sulfonylation of the resulting hydroxy group formed with mesyl chloride gave the corresponding 1-sulfonyloxyalkylphosphonates, which led to the convenient synthesis of 1-hydrazinoalky

Mesylate Derivatives of α-Hydroxy Phosphonates. Formation of Carbocations Adjacent to the Diethyl Phosphonate Group

Mesylates 3-6 have been prepared and reacted in a variety of solvents.Product, rate, and solvent effect studies implicate carbocationic intermediates in these solvolyses despite the electron-withdrawing PO(OEt)2 group.Mesylate 3 gave exclusive substitution products.Optically active 3 gave racemic products on trifluoroacetolysis. α-Deuterium isotope effects were also in line with a cationic intermediate.Mesylate 4 gave some elimination product, 27, along with the substitution product 28, also via a cationic intermediate.Mesylates 5 and 6 gave exclusive elimination products.A β-deuterium isotope effect study gave a kH6/kD6 value of 2.8.This isotope effect, along with a small m value (0.45), suggested the intermediacy of a reversibly formed ion pair which subsequently loses a proton.This mechanism represents the merging of the classical E1 mechanism and the E2C(+) mechanism, the latter representing the cationic counterpart of the E1cb mechanism.Analysis of the solvolysis rates of 3 and 4 led to the conclusion that cationic intermediates are formed quite easily.Reasons are suggested for this unexpectedly facile generation of cations adjacent to the potent electron-withdrawing PO(OEt)2 substituent.