51765-60-7Relevant articles and documents
Hyaluronic acid–nimesulide conjugates as anticancer drugs against CD44-overexpressing HT-29 colorectal cancer in vitro and in vivo
Jian, You-Sin,Chen, Ching-Wen,Lin, Chih-An,Yu, Hsiu-Ping,Lin, Hua-Yang,Liao, Ming-Yuan,Wu, Shu-Huan,Lin, Yan-Fu,Lai, Ping-Shan
, p. 2315 - 2333 (2017)
Carrier-mediated drug delivery systems are promising therapeutics for targeted delivery and improved efficacy and safety of potent cytotoxic drugs. Nimesulide is a multifactorial cyclooxygenase 2 nonsteroidal anti-inflammatory drug with analgesic, antipyr
Synthesis and biological evaluation of nimesulide based new class of triazole derivatives as potential PDE4B inhibitors against cancer cells
Mareddy, Jyoti,Nallapati, Suresh Babu,Anireddy, Jayasree,Devi, Yumnam Priyadarshini,Mangamoori, Lakshmi Narasu,Kapavarapu, Ravikumar,Pal, Sarbani
, p. 6721 - 6727 (2013)
A new class of 1,2,3-triazol derivatives derived from nimesulide was designed as potential inhibitors of PDE4B. Synthesis of these compounds was carried out via a multi-step sequence consisting of copper-catalyzed azide-alkyne cycloaddition (CuAAC) as a key step in aqueous media. The required azide was prepared via the reaction of aryl amine (obtained from nimesulide) with α-chloroacetyl chloride followed by displacing the α-chloro group by an azide. Some of the synthesized compounds showed encouraging PDE4B inhibitory properties in vitro that is >50% inhibition at 30 μM that were supported by the docking studies of these compounds at the active site of PDE4B enzyme (dock scores ～ -28.6 for a representative compound). Two of these PDE4 inhibitors showed promising cytotoxic properties against HCT-15 human colon cancer cells in vitro with IC50 ～ 21-22 μg/mL.
1,2,3-Triazole-nimesulide hybrid: Their design, synthesis and evaluation as potential anticancer agents
Mareddy, Jyoti,Suresh,Kumar, C. Ganesh,Kapavarapu, Ravikumar,Jayasree,Pal, Sarbani
, p. 518 - 523 (2017)
A new hybrid template has been designed by integrating the structural features of nimesulide and the 1,2,3-triazole moiety in a single molecular entity at the same time eliminating the problematic nitro group of nimesulide. The template has been used for
Novel molecules containing structural features of NSAIDs and 1,2,3-triazole ring: Design, synthesis and evaluation as potential cytotoxic agents
Anireddy, Jaya Shree,Banothu, Venkanna,Hossain, Kazi Amirul,Mareddy, Jyoti,Pal, Sarbani,Yadav, N. Sudhakar
, (2021/08/16)
For the first time the template containing structural features of more than one NSAIDs and the 1,2,3-triazole ring was explored for the identification of potential cytotoxic agents. These new and complex molecules were predicted to be effective inhibitors
Hydrogenation of Functionalized Nitroarenes Catalyzed by Single-Phase Pyrite FeS2 Nanoparticles on N,S-Codoped Porous Carbon
Duan, Yanan,Dong, Xiaosu,Song, Tao,Wang, Zhaozhan,Xiao, Jianliang,Yuan, Youzhu,Yang, Yong
, (2019/09/13)
Catalytic hydrogenation of nitroarenes is an industrially very important and environmentally friendly process for the production of anilines; however, highly chemoselective reduction of nitroarenes decorated with one or more reducible groups in a nitroarene molecule remains a challenge. Herein, a novel hybrid non-noble iron-based nanocatalyst (named as FeS2/NSC) was developed, which was prepared from biomass as C and N source together with inexpensive Fe(NO3)3 as Fe source through high-temperature pyrolysis in a straightforward and cost-effective procedure. Comprehensive characterization revealed that single-phase pyrite FeS2 nanoparticles with precisely defined composition and uniform size were homogeneously dispersed on N,S-codoped porous carbon with large specific surface area, hierarchical porous channels, and high pore volume. The resultant catalyst FeS2/NSC demonstrated good catalytic activity for hydrogenation of functionalized nitroarenes with good tolerance of various functional groups in water as a sustainable and green solvent. Compared with bulk pyrite FeS2 and other non-noble metal-based heterogeneous catalysts reported in the literature, a remarkably enhanced activity was observed under mild reaction conditions. More importantly, FeS2/NSC displayed exclusive chemoselectivity for the reduction of nitro groups for nitroarenes bearing varying readily reducible groups.
