51847-02-0

Basic information

• Product Name: 4-chloro-N-(2-chloroethyl)benzamide
• CAS NO: 51847-02-0
• Molecular Formula: C₉H₉Cl₂NO
• Molecular Weight: 218.0799
• Mol File: 51847-02-0.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 369.9°C at 760 mmHg
• Flash Point: 177.5°C
• Density: 1.285g/cm³
• Vapor Pressure: 1.15E-05mmHg at 25°C
• Refractive Index: 1.552
• CAS DataBase Reference: 4-chloro-N-(2-chloroethyl)benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-chloro-N-(2-chloroethyl)benzamide(51847-02-0)
• EPA Substance Registry System: 4-chloro-N-(2-chloroethyl)benzamide(51847-02-0)

Safety Data

• Hazardous Substances Data: 51847-02-0(Hazardous Substances Data)

Upstream product

• 7400-54-6 4-chloro-N-(2-hydroxyethyl)-benzamide 
• 870-24-6 2-chloroethanamine hydrochloride 
• 122-01-0 4-chloro-benzoyl chloride 
• 873-76-7 para-Chlorobenzyl alcohol 
• 59893-99-1 N-(p-chlorobenzoyl)-glycine methyl ester 

Downstream Products

• 7399-68-0 2-(4-chlorophenyl)-4,5-dihydro-1,3-oxazole 
• 13084-29-2 2-(4-chlorophenyl)-4,5-dihydro-1,3-thiazole 
• 82891-84-7 2-(4-propylphenyl)-4,5-dihydrooxazole 
• 82891-91-6 2-(2-methyl-4-chlorophenyl)-2-oxazoline 
• 82891-93-8 2-(2-methyl-4-n-propylphenyl)-2-oxazoline 
• 82891-89-2 2-<2-(methylthio)-4-chlorophenyl>-2-oxazoline 
• 71320-77-9 moclobemide 

Relevant articles and documents

Synthesis, conformational analysis and antidepressant activity of moclobemide new analogues

Three new analogues of moclobemide are synthesized. Antidepressant activity of compounds assayed by the Porsolt method reveals that the morpholine ring in moclobemide is one of the key structural parts necessary for antidepressant activity. Superimposition of norepinephrine and gauche forms of serotonin and moclobemide suggest that the phenyl ring, electronegative group attached to the aromatic ring and the amine terminal group may serve as the recognition elements for binding to monoamine oxidase-A (MAO-A).

Iron-catalyzed benzamide formation. Application to the synthesis of moclobemide

A convenient and user-friendly method to yield benzamides from primary and secondary amines and various benzylic alcohols in the presence of a cheap iron salt (FeCl2·4H2O) and tert-butylhydroperoxide (70% in water) as a stoichiometric oxidant is described. Control experiments indicated that this reaction might involve radical species. This method proved to be general, generating a family of 30 benzamides and was applied to the preparative synthesis of anti-anxiety drug moclobemide.

NOVEL METHODS FOR THE TREATMENT OF INFLAMMATORY DISEASES

Methods of inhibiting the cytokine or biological activity of Macrophage Migration Inhibitory Factor (MIF) comprising contacting MIF with a compound of formula (I) are provided. The invention also relates to methods of treating diseases or conditions where MIF cytokine or biological activity is implicated comprising administration of compounds of formula (I), either alone or as a part of combination therapy. Novel compounds of formula (I) are also provided for.