51884-11-8

Basic information

• Product Name: 5-(4-Methylphenyl)-4H-1,2,4-triazol-3-amine
• Synonyms: 5-(4-methylphenyl)-1H-1,2,4-triazol-3-amine;5-(4-Methylphenyl)-4H-1,2,4-triazol-3-amine;3-(4-methylphenyl)-1H-1,2,4-triazol-5-amine(SALTDATA: FREE);3-(4-Methylphenyl)-1H-1,2,4-triazol-5-amine;5-(p-Tolyl)-4H-1,2,4-triazol-3-aMine;[5-(4-methylphenyl)-1H-1,2,4-triazol-3-yl]amine
• CAS NO: 51884-11-8
• Molecular Formula: C₉H₁₀N₄
• Molecular Weight: 174.2
• Mol File: 51884-11-8.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 412.5 °C at 760 mmHg
• Flash Point: 232.5 °C
• Appearance: /
• Density: 1.261
• Vapor Pressure: 5.17E-07mmHg at 25°C
• Refractive Index: 1.652
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 5-(4-Methylphenyl)-4H-1,2,4-triazol-3-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(4-Methylphenyl)-4H-1,2,4-triazol-3-amine(51884-11-8)
• EPA Substance Registry System: 5-(4-Methylphenyl)-4H-1,2,4-triazol-3-amine(51884-11-8)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• HazardClass: IRRITANT
• Hazardous Substances Data: 51884-11-8(Hazardous Substances Data)

Usage

General Description

5-(4-Methylphenyl)-4H-1,2,4-triazol-3-amine is a synthetic chemical compound that belongs to the class of organic compounds known as triazoles, which are aromatic rings containing two nitrogen atoms and three carbon atoms. The compound is specifically characterized by a 1,2,4-triazole fused with a phenyl ring that carries a methyl substituent. Primarily used in research and development, this compound can act as a building block in the synthesis of more complex chemical entities. Although there is currently limited information about its toxicity, bioactivity, or commercial use, as a chemical research tool it may demonstrate distinct biological or pharmacological activity.

InChI:InChI=1/C9H10N4/c1-6-2-4-7(5-3-6)8-11-9(10)13-12-8/h2-5H,1H3,(H3,10,11,12,13)

Upstream product

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Relevant articles and documents

Diversity-Oriented Synthesis of 1,2,4-Triazols, 1,3,4-Thiadiazols, and 1,3,4-Selenadiazoles from N-Tosylhydrazones

The diversity-oriented synthesis of 1,2,4-triazols, 1,3,4-thiadiazols, and 1,3,4-selenadiazoles from N-tosylhydrazones was developed, and the reactions were general for a wide range of substrates, in which NH2CN, KOCN, KSCN, and KSeCN were used as odorless sources. Two different pathways were proposed, and N-tosylhydrazonoyl chlorides were formed in situ in the presence of NCS.

Synthesis and in vitro anti-epileptic activities of novel [1,2,4]-triazolo[1,5-a]pyrimidin-7(4H)-one derivatives

In this investigation, eight novel 2,5-disubstituted [1,2,4]-triazolo[1,5-a]pyrimidin-7(4H)-one and eight novel 2,5-disubstituted [1,2,4]-triazolo[1,5-a]pyrimidine amine derivatives were synthesized based on the novel marine natural product Essramycin. Their anti-epileptic activities were evaluated by 4-aminopyridine (4-AP)-induced hyper excitability model in primary cultured neocortical neurons. Five compounds with [1,2,4]-triazolo[1,5-a]pyrimidin-7(4H)-one skeleton showed remarkable anti-epileptic activities. The preliminary structure–activity relationship (SAR) showed that the pyrimidine-7(4H)-one motif is the necessary “active core” of anti-epileptic activity. To understand the action mechanism of anti-epileptic activity of [1,2,4]-triazolo[1,5-a]pyrimidin-7(4H)-one compounds, docking studies using the model of GABAA as docking scaffolds were performed and the docking results were in concordance with the experiment observations. (Figure presented.).