51887-89-9

Basic information

• Product Name: 3-CHLORO-L-ALANINE HYDROCHLORIDE
• Synonyms: H-ALA(3-CL)-OH HCL;H-BETA-CHLORO-ALA-OH HCL;(R)-2-AMINO-3-CHLOROPROPIONIC ACID HYDROCHLORIDE;B-CHLORO-L-ALANINE HYDROCHLORIDE;3-Chloro-L-alanineHCl;β-chloro-l-alanine hydrochloride;3-CHLORO-L-ALANINE HYDROCHLORIDE 98+%;H-b-Chloro-Ala-OH·HCl
• CAS NO: 51887-89-9
• Molecular Formula: C₃H₆ClNO₂*ClH
• Molecular Weight: 160
• EINECS: 200-528-9
• Product Categories: Carboxylic Acids (Chiral);Chiral Building Blocks;Synthetic Organic Chemistry;A;AA to ALCertified Reference Materials (CRMs);Alphabetic;Application CRMs;Clinical Chemistry CRM;Alanine aminotransferase;Alanine aminotransferasePeptides for Cell Biology;A to;Enzyme Inhibitors;Enzyme Inhibitors by Enzyme
• Mol File: 51887-89-9.mol
• Article Data: 5

Chemical Properties

• Melting Point: 205 °C (dec.)(lit.)
• Boiling Point: 243.6 °C at 760 mmHg
• Flash Point: 101.1 °C
• Appearance: /
• Density: 1.401 g/cm³
• Vapor Pressure: 0.0105mmHg at 25°C
• Storage Temp.: −20°C
• CAS DataBase Reference: 3-CHLORO-L-ALANINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-CHLORO-L-ALANINE HYDROCHLORIDE(51887-89-9)
• EPA Substance Registry System: 3-CHLORO-L-ALANINE HYDROCHLORIDE(51887-89-9)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 51887-89-9(Hazardous Substances Data)

Usage

Description

3-CHLORO-L-ALANINE HYDROCHLORIDE is a white solid that is a derivative of the amino acid L-alanine, with a chlorine atom attached at the third position. It is a compound of significant interest in various scientific and industrial applications due to its unique chemical properties.

Uses

Used in Enzyme Kinetics Studies:
3-CHLORO-L-ALANINE HYDROCHLORIDE is used as a substrate for screening tyrosine phenol lyase steady state kinetics. This application is crucial in understanding the enzyme's activity and its role in various biochemical processes.
Used in Cellular and Molecular Biology Research:
In the inhibition of serine palmitoyltransferase and cytotoxicity studies in lymphocyte Ly-1 cells, 3-CHLORO-L-ALANINE HYDROCHLORIDE serves as a valuable tool. This application aids in investigating the enzyme's function and its impact on cell viability and function.
Used in Protein Synthesis Systems:
3-CHLORO-L-ALANINE HYDROCHLORIDE is used as an inhibitor of alanine transaminase in wheat germ cell-free protein synthesis systems. This application is essential for studying the regulation of protein synthesis and the role of alanine transaminase in this process.

Biochem/physiol Actions

β-Chloro-L-alanine hydrochloride is an inhibitor of alanine aminotransferase (ALAT). Inhibition of ALAT leads to suppression of tumor progression in lung carcinoma.

InChI:InChI=1/C3H6ClNO2.ClH/c4-1-2(5)3(6)7;/h2H,1,5H2,(H,6,7);1H/t2-;/m0./s1

Upstream product

• 112839-92-6 O-(trifluoroacetyl)-L-serine p-toluenesulfonic acid salt 
• 17136-54-8 Methyl (2R)-2-amino-3-chloropropionate hydrochloride 
• 16428-75-4 D,L-serine hydrochloride 
• 56-45-1 L-serin 

Downstream Products

• 7625-65-2 L-carbobenzyloxy-β-chloroalanine 
• 96099-72-8 (2R)-S-cysteine 
• 96150-12-8 (2S,3R)-3-((R)-2-Amino-2-carboxy-ethylsulfanyl)-2-benzyloxycarbonylamino-butyric acid 
• 212651-52-0 (2R)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-chloropropionic acid 
• 1464-43-3 seleno-L-cystine 
• 56-88-2 L-cystathionine 
• 2731-73-9 2-amino-3-chloropropanoic acid 

Relevant articles and documents

Method for synthesizing L -selenium - methylselenocysteine

The invention provides a method for synthesizing L -selenium - methylselenocysteine, and relates to the reaction of a compound of formula II or a salt thereof with dimethyl diselenoate, and the method comprises MBH. 4 The method comprises the following steps: directly synthesizing L - selenium - methylselenocysteine through a one-pot reaction under the action of alkali or synthesizing L - selenium - methylselenocysteine, and hydrolyzing to obtain L - selenium - methylselenocysteine. The synthesis method has the advantages of simple reaction. The method has the advantages of convenient operation, high product yield, good quality, low cost and suitability for industrialization.

Preparation method for L-selenocysteine

The invention belongs to the field of chemical synthesis, and concretely relates to a synthetic method for L-selenocysteine. The method comprises the following steps: a, chloridizing L-serine hydrochloride to obtain 3-chloro-L-alanine hydrochloride; b, performing seleno-reaction of 3-chloro-L-alanine hydrochloride prepared by step a under alkaline condition to obtain L-selenocystine; and c, performing reduction reaction of L-selenocystine to obtain L-selenocysteine. The method has simple steps, high yield, low cost, and good application prospect.

Direct synthesis of Fmoc-protected amino acids using organozinc chemistry: Application to polymethoxylated phenylalanines and 4-oxoamino acids

The newN-Fmoc 3-iodoalaninetert-butyl ester derived organozinc reagent1, obtained in 7 steps from optically pure 3-serine, was coupled to a range of electrophiles under palladium catalysis to give substituted phenylalanines and 4-oxoamino acids in variabl