5189-11-7

Basic information

• Product Name: Pizotifen Malate
• Synonyms: sandomygranmalate;sanomtgran;4-(9,10-DIHYDRO-1-THIA-BENZO[F]AZULEN-4-YLIDENE)-1-METHYL-PIPERIDINE, COMPOUND WITH 2-HYDROXY-SUCCINIC ACID;PIZOTYLINE MALATE;PIZOTIFEN MALATE;9,10-Dihydro-4-(1-methylpiperidin-4-ylidene)-4H-benzo[4,5]cyclohepta[1,2-b]thiophene malate (1:1);malic acid, compound with 4-(9,10-dihydro-4H-benzo[4,5]cyclohepta[1,2-b]thien-4-ylidene)-1-methylpiperidine (1:1);Einecs 225-970-4
• CAS NO: 5189-11-7
• Molecular Formula: C23H27NO5S
• Molecular Weight: 429.53
• EINECS: 225-970-4
• Product Categories: Active Pharmaceutical Ingredients;Sandomigran, pizotyline
• Mol File: 5189-11-7.mol
• Article Data: 0

Chemical Properties

• Melting Point: 185-186° (dec)
• Boiling Point: 436.7 °C at 760 mmHg
• Flash Point: 217.9 °C
• Appearance: /
• Density: 1.164 g/cm³
• Vapor Pressure: 7.92E-08mmHg at 25°C
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• Solubility: Aqueous Acid (Slightly, Heated), DMSO (Slightly), Methanol (Slightly)
• Stability: Hygroscopic
• CAS DataBase Reference: Pizotifen Malate(CAS DataBase Reference)
• NIST Chemistry Reference: Pizotifen Malate(5189-11-7)
• EPA Substance Registry System: Pizotifen Malate(5189-11-7)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39
• Hazardous Substances Data: 5189-11-7(Hazardous Substances Data)

Usage

Description

Pizotifen Malate, also known as C19H21NS·C4H6O5, is a malate salt resulting from the reaction of equimolar amounts of pizotifen and malic acid. It is a sedating antihistamine with strong serotonin antagonist and weak antimuscarinic activity. Pizotifen Malate is primarily recognized for its antiserotonergic properties and is a member of the piperidine derivatives.

Uses

Used in Pharmaceutical Industry:
Pizotifen Malate is used as an antimigraine drug for the treatment of migraine and the prevention of headache attacks during cluster periods. It is particularly effective due to its strong serotonin antagonist properties, which help alleviate migraine symptoms.
Used in Antimigraine Applications:
Pizotifen Malate is used as an anti migraine drug, providing relief from migraine symptoms and preventing headache attacks during cluster periods. Its antiserotonergic properties make it a valuable asset in managing migraine conditions.

InChI:InChI=1/C19H21NS.C4H6O5/c1-20-11-8-15(9-12-20)19-16-5-3-2-4-14(16)6-7-18-17(19)10-13-21-18;5-2(4(8)9)1-3(6)7/h2-5,10,13H,6-9,11-12H2,1H3;2,5H,1H2,(H,6,7)(H,8,9)