518987-75-2

Basic information

• Product Name: 5-CYANO INDAZOLE-3-CARBOXALDEHYDE
• Synonyms: 5-CYANO INDAZOLE-3-CARBOXALDEHYDE;5-Cyano-1H-indazole-3-carboxyaldehyde;3-formyl-1H-indazole-5-carbonitrile;5-Cyano-1H-indazole-3-carbaldehyde;5-CYANO-1H-INDAZOLE-3-CARBOXALDEHYDE
• CAS NO: 518987-75-2
• Molecular Formula: C₉H₅N₃O
• Molecular Weight: 171.16
• Mol File: 518987-75-2.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-CYANO INDAZOLE-3-CARBOXALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-CYANO INDAZOLE-3-CARBOXALDEHYDE(518987-75-2)
• EPA Substance Registry System: 5-CYANO INDAZOLE-3-CARBOXALDEHYDE(518987-75-2)

Safety Data

• Hazardous Substances Data: 518987-75-2(Hazardous Substances Data)

Usage

General Description

5-CYANO INDAZOLE-3-CARBOXALDEHYDE is a chemical compound with the molecular formula C10H7N3O. It is a derivative of indazole, a heterocyclic aromatic organic compound. The presence of a cyano group and a carboxaldehyde group in the molecule makes it an important precursor for the synthesis of various pharmaceuticals, agrochemicals, and dyes. 5-CYANO INDAZOLE-3-CARBOXALDEHYDE has been used in the development of potential anti-cancer and anti-inflammatory drugs. Its structural properties and reactivity have also made it a valuable intermediate in organic synthesis. Additionally, 5-CYANO INDAZOLE-3-CARBOXALDEHYDE is being studied for its potential applications in materials science and as a building block for the synthesis of novel organic compounds.

Upstream product

• 15861-24-2 1H-indole-5-carbonitrile 

Downstream Products

• 677702-48-6 3-Formyl-1-(2,4,6-trimethylbenzenesulphonyl)-1H-indazole-5-carbonitrile 

Relevant articles and documents

An optimized procedure for direct access to 1: H -indazole-3-carboxaldehyde derivatives by nitrosation of indoles

Indazole derivatives are currently drawing more and more attention in medicinal chemistry as kinase inhibitors. 1H-indazole-3-carboxaldehydes are key intermediates to access to a variety of polyfunctionalized 3-substituted indazoles. We report here a general access to this motif, based on the nitrosation of indoles in a slightly acidic environment. These very mild conditions allow the conversion of both electron-rich and electron-deficient indoles into 1H-indazole-3-carboxaldehydes.

Indazolecarboxamide derivatives, preparation and use thereof as CDK1, CDK2 and CDK4 inhibitors

Compound corresponding to general formula (I): [image] in which, R1 represents a hydrogen or halogen atom, an NH2, NHR2, NHCOR2, NO2, CN, CH2NH2 and CH2NHR2; or alternatively R1 represents an optionally substituted phenyl or an optionally substituted heteroaromatic group; Ar represents an optionally substituted phenyl group or an optionally substituted heteroaromatic group; n represents 0, 1, 2 or 3; in the form of a base, of an addition salt with an acid, of a hydrate or of a solvate. Application in therapy.