51933-79-0

Basic information

• Product Name: 3-methyl-2-phenoxypyridine
• Synonyms: 3-methyl-2-phenoxypyridine
• CAS NO: 51933-79-0
• Molecular Weight: 185.225
• Mol File: 51933-79-0.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 3-methyl-2-phenoxypyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-methyl-2-phenoxypyridine(51933-79-0)
• EPA Substance Registry System: 3-methyl-2-phenoxypyridine(51933-79-0)

Safety Data

• Hazardous Substances Data: 51933-79-0(Hazardous Substances Data)

Upstream product

• 1003-56-1 3-Methyl-1H-pyridin-2-one 
• 26838-86-8 pyridine-2-carboxylic acid phenyl ester 
• 4021-07-2 3-methyl-pyridine-2-carboxylic acid 
• 108-95-2 phenol 
• 118-92-3 anthranilic acid 
• 18368-76-8 2 chloro-3-methylpyridine 
• 100-67-4 potassium phenolate 

Relevant articles and documents

N - And O -arylation of pyridin-2-ones with diaryliodonium salts: Base-dependent orthogonal selectivity under metal-free conditions

Metal-free N- and O-arylation reactions of pyridin-2-ones as ambident nucleophiles have been achieved with diaryliodonium salts on the basis of base-dependent chemoselectivity. In the presence of N,N-diethylaniline in fluorobenzene, pyridin-2-ones were very selectively converted to N-arylated products in high yields. On the other hand, the O-arylation reactions smoothly proceeded with the use of quinoline in chlorobenzene, leading to high yields and selectivities. In these methods, a variety of pyridin-2-ones in addition to pyridin-4-one and a set of diaryliodonium salts were accepted as suitable reaction partners.

Decarbonylative Diaryl Ether Synthesis by Pd and Ni Catalysis

Because diaryl ethers are present as an important motif in pharmaceuticals and natural products, extensive studies for the development of novel methods have been conducted. A conventional method for the construction of the diaryl ether moiety is the intermolecular cross-coupling reaction of aryl halides and phenols with a copper or palladium catalyst. We developed a catalytic decarbonylative etherification of aromatic esters using a palladium or nickel catalyst with our enabling diphosphine ligand to give the corresponding diaryl ethers. The present reaction can be conducted on gram scale in excellent yield. This reaction not only functions in an intramolecular setting but also allows for a cross-etherification using other phenols.

SYNTHESIS OF PHENOXYPYRIDINES UNDER PHASE TRANSFER CATALYSIS CONDITIONS

Reactions of halopyridines with alkali metal phenoxides in a two phase liquid-solid catalytic system, rather than in a liquid-liquid phase transfer catalytic system, make it possible to prepare 2-, 3-, and 4-phenoxypyridines from unactivated bromo- or chloropyridines and 2-chloropicolines.In polyhalogenated pyridines only α- and γ-halogen atoms undergo substitution. 7,8-Dibromo-6-azaphenoxane has been prepared by the reaction of 2,3,5,6-tetrabromopyridine with the dipotassium salt of pyrocatechol.