5196-20-3

Basic information

• Product Name: 1,3-dihydro-6-methylfuro[3,4-c]pyridin-7-ol
• Synonyms: 1,3-dihydro-6-methylfuro[3,4-c]pyridin-7-ol;Einecs 225-981-4;3-methyl-8-oxa-4-azabicyclo[4.3.0]nona-1,3,5-trien-2-ol;Pyridoxine Cyclic Ether IMpurity;6-Methyl-1H,3H-furo[3,4-c]pyridin-7-ol;6-Methyl-1,3-dihydrofuro[3,4-c]pyridin-7-ol
• CAS NO: 5196-20-3
• Molecular Formula: C₈H₉NO₂
• Molecular Weight: 151.16256
• EINECS: 225-981-4
• Product Categories: Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 5196-20-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 358.5 °C at 760 mmHg
• Flash Point: 170.6 °C
• Appearance: /
• Density: 1.286±0.06 g/cm3 (20 ºC 760 Torr)
• Vapor Pressure: 1.23E-05mmHg at 25°C
• Refractive Index: 1.6
• Storage Temp.: 2-8°C
• PKA: 5.49±0.20(Predicted)
• CAS DataBase Reference: 1,3-dihydro-6-methylfuro[3,4-c]pyridin-7-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-dihydro-6-methylfuro[3,4-c]pyridin-7-ol(5196-20-3)
• EPA Substance Registry System: 1,3-dihydro-6-methylfuro[3,4-c]pyridin-7-ol(5196-20-3)

Safety Data

• RIDADR: UN 2811 6.1 / PGIII
• Hazardous Substances Data: 5196-20-3(Hazardous Substances Data)

Usage

Description

1,3-dihydro-6-methylfuro[3,4-c]pyridin-7-ol is an organic compound that serves as a key intermediate in the synthesis of various pharmaceuticals and vitamins. It is characterized by its unique chemical structure, which includes a furo and pyridin ring fused together, and a methyl group attached to the pyridin ring. 1,3-dihydro-6-methylfuro[3,4-c]pyridin-7-ol plays a crucial role in the development of essential nutrients and therapeutic agents.

Uses

Used in Pharmaceutical Industry:
1,3-dihydro-6-methylfuro[3,4-c]pyridin-7-ol is used as an intermediate in the synthesis of pyridoxine (vitamin B6) for its essential role in various metabolic processes in the human body. Vitamin B6 is vital for the proper functioning of the nervous system, immune system, and the synthesis of amino acids, which are the building blocks of proteins.
Used in Vitamin Production:
1,3-dihydro-6-methylfuro[3,4-c]pyridin-7-ol is used as a precursor in the production of vitamin B6, which is an essential nutrient that plays a critical role in the metabolism of carbohydrates, fats, and proteins. It also supports the production of neurotransmitters, which are essential for proper brain function and the regulation of mood.

InChI:InChI=1/C8H9NO2/c1-5-8(10)7-4-11-3-6(7)2-9-5/h2,10H,3-4H2,1H3

Upstream product

• 65-23-6 5-hydroxy-6-methyl-3,4-pyridinedimethanol 
• 880-91-1 1-ethoxy-7-hydroxy-6-methyl-1,3-dihydrofuro[3,4-c]pyridin-7-ol 
• 92757-43-2 6-methyl-7-(trimethylsilyl)-1,3-dihydrofuro<3,4-c>pyridin-5-oxid 
• 856412-06-1 6-methyl-7-(dimethylisopropoxysilyl)-1,3-dihydrofuro[3,4-c]pyridine 
• 856412-04-9 3,3-bis(dimethylisopropoxysilyl)-di-2-propynyl ether 
• 856412-05-0 6-methyl-4,7-bis(dimethylisopropoxysilyl)-1,3-dihydrofuro[3,4-c]pyridine 
• 6921-27-3 dipropargyl ether 
• 18036-67-4 bis<3-(trimethylsilyl)-2-propinyl>aether 
• 92757-45-4 trimethyl (3-(2-(prop-2-yn-1-yloxy)ethoxy)prop-1-yn-1-yl)silane 
• 92757-80-7 6-methyl-4,7-bis(trimethylsilyl)-1,3-dihydrofuro<3,4-c>pyridin 
• 92757-46-5 4-<3-(trimethylsilyl)-2-propinyl>oxy-2-butinsaeure 
• 92757-47-6 4-<3-(trimethylsilyl)-2-propinyl>oxy-2-butinsaeure-aethylester 
• 92757-51-2 6-methyl-1,3-dihydrofuro<3,4-c>pyridin-7-carbonsaeure 
• 92757-50-1 6-methyl-1,3-dihydrofuro<3,4-c>pyridin-7-carbonsaeure-aethylester 

Relevant articles and documents

An improved synthesis of pyridoxine via [2+2+2] cyclization of acetylenes and nitriles

An improved synthesis of pyridoxine (vitamin B6) is reported. The key step involves the light-promoted [2+2+2] cyclization of 3,3-bissilyl-di-2-propynyl ethers and acetonitrile in the presence of [cpCo(cod)] (1 mol%) as a catalyst. Convenient oxidation and iodination procedures are elaborated to transfer 3-silylpyridines into corresponding 3-hydroxy- and 3-iodo-derivatives.

Cobalt-catalyzed cycloaddition of alkynes and nitriles to pyridines: A new route to pyridoxine (vitamin B6)

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