520-36-5Relevant articles and documents
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Dranik
, (1970)
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Regioselective ortho-Hydroxylations of Flavonoids by Yeast
Sordon, Sandra,Madej, Anna,Pop?oński, Jaros?aw,Bartmańska, Agnieszka,Tronina, Tomasz,Brzezowska, Ewa,Juszczyk, Piotr,Huszcza, Ewa
, p. 5525 - 5530 (2016)
Natural flavonoids, such as naringenin, hesperetin, chrysin, apigenin, luteolin, quercetin, epicatechin, and biochanin A, were subjected to microbiological transformations by Rhodotorula glutinis. Yeast was able to regioselectively C-8 hydroxylate hesperetin, luteolin, and chrysin. Naringenin was transformed to 8- and 6-hydroxyderivatives. Quercetin, epicatechin, and biochanin A did not undergo biotransformation. A metabolic pathway for the degradation of chrysin has been elucidated. The metabolism of chrysin proceeds via an initial C-8 hydroxylation to norwogonin, followed by A-ring cleavage to 4-hydroxy-6-phenyl-2H-pyran-2-one.
Secondary metabolites of an Algerian Phlomis bovei and their antioxidant activities
Zaabat,Akkal,Darboure,Laouer,Franca, M. G. Dijoux,Duddeck, Helmut
, p. 454 - 455 (2010)
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Gusev et al.
, (1977)
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FLAVONOID GLYCOSIDES OF ARTEMISIA MONOSPERMA AND A. HERBA-ALBA
Saleh, Nabiel A. M.,El-Negoumy, Sabry I.,Abd-Alla, Mohamed F.,Abou-Zaid, Mamdouh M.,Dellamonica, G.,Chopin, J.
, p. 201 - 203 (1985)
Ten flavonoid glycosides were isolated and identified from Artemisia monosperma: vicenin-2, lucenin-2, acacetin 7-glucoside, acacetin 7-rutinoside, the 3-glucosides and 3-rutinosides of quercetin and patuletin, and the 5-glucosides of quercetin and isorhamnetin.From Artemisia herba-alba eight flavonoid glycosides were isolated and identified: isovitexin, vicenin-2, schaftoside, isoschaftoside and the 3-glucosides and 3-rutinosides of quercetin and patuletin.Key Word Index - Artemisia monosperma; A herba-alba; Compositae; flavone and flavonol glycosides.
A NEW GLYCOSYLATED FLAVONOID, 7-O-α-L-RHAMNOPYRANOSYL-4'-O-RUTINOSYLAPIGENIN, IN THE EXUDATE FROM GERMINATING SEEDS OF Sesbania rostrata
Messems, Eric,Montagu, Marc Van,Bruyn, Andre De,Jans, Arnold W. H.
, p. 241 - 254 (1989)
The title apigenin triglycoside was isolated (4 mg/6000 seeds) by reversephase column chromatography as the major u.v.-absorbing compound in the exudate of germinating seeds of Sesbania rostrata.The structure was assigned on the basis of u.v. spectra, f.a.b.-mass-spectral and 2D-n.m.r. data.The triglycoside was released continuously from the germinating seeds, but at a decreasing rate during the first two weeks.
Discovery of Novel Apigenin-Piperazine Hybrids as Potent and Selective Poly (ADP-Ribose) Polymerase-1 (PARP-1) Inhibitors for the Treatment of Cancer
Long, Huan,Hu, Xiaolong,Wang, Baolin,Wang, Quan,Wang, Rong,Liu, Shumeng,Xiong, Fei,Jiang, Zhenzhou,Zhang, Xiao-Qi,Ye, Wen-Cai,Wang, Hao
, p. 12089 - 12108 (2021/09/06)
Poly (ADP-ribose) polymerase-1 (PARP-1) is a potential target for the discovery of chemosensitizers and anticancer drugs. Amentoflavone (AMF) is reported to be a selective PARP-1 inhibitor. Here, structural modifications and trimming of AMF have led to a series of AMF derivatives (9a-h) and apigenin-piperazine/piperidine hybrids (14a-p, 15a-p, 17a-h, and 19a-f), respectively. Among these compounds, 15l exhibited a potent PARP-1 inhibitory effect (IC50 = 14.7 nM) and possessed high selectivity to PARP-1 over PARP-2 (61.2-fold). Molecular dynamics simulation and the cellular thermal shift assay revealed that 15l directly bound to the PARP-1 structure. In in vitro and in vivo studies, 15l showed a potent chemotherapy sensitizing effect against A549 cells and a selective cytotoxic effect toward SK-OV-3 cells through PARP-1 inhibition. 15l·2HCl also displayed good ADME characteristics, pharmacokinetic parameters, and a desirable safety margin. These findings demonstrated that 15l·2HCl may serve as a lead compound for chemosensitizers and the (BRCA-1)-deficient cancer therapy.
Extraction, Isolation and Characterization of Valuable Worked on Acacia Tortilis
Muhaisen, Hasan M. H.
, p. 6731 - 6747 (2021/11/01)
Acacia tortilis is one of the important species of genus Acacia belonging to family Leguminaceae. Though there is no more study performed on this plant but it plays important role in the countries where it found. These countries include North Africa, Arabian Peninsula and Asian countries. The various part of Acacia tortilis plant say leaves, pods, gum exudates and bark were used as antidiabetic, antidiarrhoeal, antiasthmatic and also had several other medicinal benefits. The present discussion deals with the isolation and characterization of the following compounds from the leaves of Acacia tortilis. Lupan-3-ol, 12,20-diene, Lupan-12, 20-dien 3-one, Friedelin, ?-amyrin, ?- sitosterol, Apigenin, Luteolin, Quercetin, 5,7-dihydroxy-4-p-methyl benzylisoflavone, Vitexin, 2',6'-dihydroxy chalcone-4'-O-glucoside.