52024-31-4

Basic information

• Product Name: Pyridine, 5-nitro-2-[(phenylmethyl)thio]-
• CAS NO: 52024-31-4
• Molecular Formula: C12H10N2O2S
• Molecular Weight: 246.29
• Mol File: 52024-31-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Pyridine, 5-nitro-2-[(phenylmethyl)thio]-(CAS DataBase Reference)
• NIST Chemistry Reference: Pyridine, 5-nitro-2-[(phenylmethyl)thio]-(52024-31-4)
• EPA Substance Registry System: Pyridine, 5-nitro-2-[(phenylmethyl)thio]-(52024-31-4)

Safety Data

• Hazardous Substances Data: 52024-31-4(Hazardous Substances Data)

Upstream product

• 4548-45-2 2-chloro-5-nitropyridine 
• 100-53-8 phenylmethanethiol 
• 100-51-6 benzyl alcohol 
• 2127-09-5 2-mercapto-5-nitropyridine 
• 100-39-0 benzyl bromide 

Downstream Products

• 52024-32-5 5-amino-2-(benzylthio)pyridine 

Relevant articles and documents

USP30 INHIBITORS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of USP30, and the treatment of USP30-mediated disorders.

Efficient Generation of C–S Bonds via a By-Product-Promoted Selective Coupling of Alcohols, Organic Halides, and Thiourea

A metal- and base-free three-component coupling of alcohols, heteroaryl halides, and thiourea has been developed for direct and selective synthesis of heteroaryl thioethers. This method can be easily scaled up to the gram scale and extended to dialkyl thioethers, heteroaryl selenides, benzothiazoles, and some antimycobacterially-active thioethers. Mechanistic studies revealed that a by-product-promoted in situ C–O activation of alcohols to more reactive alkyl halides and slow release of the thiol and alkyl halide intermediates are the key to the high selectivity and success of the reaction. (Figure presented.).