52096-24-9Relevant articles and documents
Protonated alkylpyrazole ionic liquid and method using same for synthesizing cyclic carbonate
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Paragraph 0026; 0028, (2018/01/12)
The invention relates to protonated alkylpyrazole ionic liquid with a structural formula as shown in the description, wherein n is equal to 1, 2, 3 or 4, and X is Cl, Br or I. The invention further discloses a method for synthesizing cyclic carbonate by using the protonated alkylpyrazole ionic liquid; the protonated alkylpyrazole ionic liquid and an epoxy compound are added into a high-pressure reaction kettle according to a molar ratio of 1 : (25 to 300), CO2 is introduced until pressure is 1-3 MPa, and constant-temperature constant-pressure reaction is performed for 1-5 hours at a temperature of 100-150 DEG C, and post-treatment is performed after reaction is ended, thus obtaining the cyclic carbonate. The method solves the problems that CO2 activation is difficulty, a catalyst is dear, a poisonous organic solvent is used, a synthesis process is complex, reaction conditions are harsh and the like in an existing method. The advantages of simple synthesis process, high catalyst activity, environmental friendliness, low cost and the like are achieved.
SMALL MOLECULE INHIBITORS OF IL-6 AND USES THEREOF
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Paragraph 00932, (2013/03/26)
In one aspect, the invention relates to substituted 2-(lH-indol-3-yl)ethanol analogs and substituted 3,3a,8,8a-tetrahydro-2H-furo[2,3-b]indole analogs, derivatives thereof, and related compounds, which are useful as inhibitors of IL-6 mediated activation of the Jak2/STAT3 pathway; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating disorders of uncontrolled cellular proliferation associated with a IL6 dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
4-AMINO-5-METHYLPYRAZOLE DERIVATIVES AND PROCESS FOR PRODUCTION THEREOF
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Page/Page column 32, (2010/02/14)
The present invention relates to 4-amino-5-methylpyrazole derivatives represented by the following formula (I): (wherein R1 represents an isobutyl group, a cyclobutylmethyl group, a neopentyl group or the like) or a salt thereof, which are novel compounds being useful as synthetic intermediates of pharmaceuticals, agricultural chemicals or the like.