521-12-0

Basic information

• Product Name: Drostanolone propionate
• Synonyms: 17β-Hydroxy-2α-methyl-5α-androstan-3-one propionate;17β-Hydroxy-2α-methylandrostan-3-one propionate;2α-Methyl-17β-hydroxy-5α-androstan-3-one 17-propionate;2α-Methyl-17β-propionoxy-5α-androstan-3-one;2α-Methyl-4,5-dihydrotestosterone propionate;2α-Methylandrostan-17(β)-ol-3-one propionate;2α-Methylandrostan-17β-ol-3-one propionate;2α-Methyldihydrotestosterone propionate
• CAS NO: 521-12-0
• Molecular Formula: C₂₃H₃₆O₃
• Molecular Weight: 360.53
• EINECS: 208-303-1
• Product Categories: Intermediates & Fine Chemicals;Pharmaceuticals;Steroids;Steroid and Hormone;materon
• Mol File: 521-12-0.mol
• Article Data: 0

Chemical Properties

• Melting Point: 114-120°C
• Boiling Point: 432.53°C (rough estimate)
• Flash Point: 190.495 °C
• Appearance: White Solid
• Density: 1.0669 (rough estimate)
• Vapor Pressure: 3.81E-08mmHg at 25°C
• Refractive Index: 1.4700 (estimate)
• Storage Temp.: Controlled Substance, -20?C Freezer
• CAS DataBase Reference: Drostanolone propionate(CAS DataBase Reference)
• NIST Chemistry Reference: Drostanolone propionate(521-12-0)
• EPA Substance Registry System: Drostanolone propionate(521-12-0)

Safety Data

• Hazardous Substances Data: 521-12-0(Hazardous Substances Data)

Usage

Description

Drostanolone propionate, also known as 17b-Hydroxy-2a-methyl-5a-androstan-3-one propionate, is a synthetic anabolic-androgenic steroid with similar properties to dihydrotestosterone. It is a white solid and has been used historically for the treatment of breast cancer. Currently, it is primarily utilized by athletes and bodybuilders to enhance physical performance and health, including muscle buildup and fat loss. It is administered via intramuscular injection.

Uses

Used in Antineoplastic Applications:
Drostanolone propionate is used as an antineoplastic agent for the palliation of androgen-responsive recurrent mammary cancer in women who are more than one year but less than five years postmenopausal.
Used in Athletic Performance Enhancement:
Drostanolone propionate is used as a performance-enhancing drug to improve athletic performance, including endurance and strength, for athletes and bodybuilders.
Used in Muscle Gain and Fat Loss:
Drostanolone propionate is used as an anabolic steroid to promote muscle gain and fat loss, enhancing the physical health of athletes and bodybuilders.

Antiestrogenic effects

Dromostanolone Propionate is the propionate salt form of dromostanolone, a synthetic anabolic steroid related to dihydrotestosterone that has antiestrogenic effects. Dromostanolone inhibits the growth of estrogen receptor-presenting breast cancers; its virilizing effects limit its clinical usefulness.Drostanolone propionate is a modified form of drostanolone, where a carboxylic acid ester (propionic acid) has been attached to the 17-beta hydroxyl group.Drostanolone Propionate is a synthetic androgenic anabolic steroid and is approximately 5 times as potent as natural methyltestosterone.

Physiological effect

Like testosterone and other androgenic hormones, dromostanolone binds to the androgen receptor. This causes downstream genetic transcriptional changes. This ultimately causes retention of nitrogen, potassium, and phosphorus; increases protein anabolism; and decreases amino acid catabolism. The antitumour activity of dromostanolone appears related to reduction or competitive inhibition of prolactin receptors or estrogen receptors or production.Specifically, Masteron is the DHT hormone that has been structurally altered by the addition of a methyl group at the carbon 2 position, This protects the hormone from the metabolic breakdown by the 3-hydroxysteroid dehydrogenase enzyme, which is found in the skeletal muscle.

Preparation

Drostanolone propionate is prepared from 9,11-dehydro-17a-methyl-testosterone raw material, reacts with lithium chloride and N-chlorosuccinimide to generate 9a,11-dichloro-17a-methyl- 95 testosterone is further prepared by esterification with propionin.

Therapeutic Function

Cancer chemotherapy

Side effects

As to be expected with all steroids, it's essential that you're aware of all potential side effects of Drostanolone propionate, before you consider a cycle. Side effects of drostanolone propionate include symptoms of masculinization like acne, increased hair growth, voice changes, and increased sexual desire. It has no risk of liver damage.

References

https://en.wikipedia.org/wiki/Drostanolone_propionate http://www.chemspider.com/Chemical-Structure.194604.html http://steroid.es/drostanolone.html Chowdhury, M. S., et al. "A comparison of drostanolone propionate (Masteril) and nandrolone decanoate (Deca-durabolin) in the treatment of breast carcinoma. " 2.3(1976):203-206.

InChI:InChI=1/C23H36O3/c1-5-21(25)26-20-9-8-17-16-7-6-15-12-19(24)14(2)13-23(15,4)18(16)10-11-22(17,20)3/h14-18,20H,5-13H2,1-4H3/t14-,15+,16+,17+,18+,20+,22+,23+/m1/s1

Downstream Products

• 1923-17-7 17β-acetoxy-2α-methyl-5α-androstan-3-one 
• 58-19-5 dromostanolone