52122-98-2

Basic information

• Product Name: 1H-Imidazole-4,5-dicarboxylic acid, 2-phenyl-, 4,5-dimethyl ester
• Synonyms: 1H-Imidazole-4,5-dicarboxylic acid, 2-phenyl-, 4,5-dimethyl ester;HHXCJFMOJFOZCJ-UHFFFAOYSA-N
• CAS NO: 52122-98-2
• Molecular Formula: C₁₃H₁₂N₂O₄
• Molecular Weight: 260.25
• Mol File: 52122-98-2.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1H-Imidazole-4,5-dicarboxylic acid, 2-phenyl-, 4,5-dimethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Imidazole-4,5-dicarboxylic acid, 2-phenyl-, 4,5-dimethyl ester(52122-98-2)
• EPA Substance Registry System: 1H-Imidazole-4,5-dicarboxylic acid, 2-phenyl-, 4,5-dimethyl ester(52122-98-2)

Safety Data

• Hazardous Substances Data: 52122-98-2(Hazardous Substances Data)

Usage

Derivative of imidazole

The compound is based on the imidazole structure, which is a five-membered heterocyclic ring containing three carbon atoms and two nitrogen atoms.

Ester

The compound contains a carbonyl group (C=O) bonded to an oxygen atom (O), indicating the presence of an ester functional group.

Two methyl groups

The imidazole ring in the compound has two methyl (CH3) groups attached to it, which can affect its reactivity and physical properties.

Used in synthesis

The compound is used as a building block or intermediate in the synthesis of various pharmaceuticals, agrochemicals, and other organic compounds due to its versatile reactivity and biological activity.

Upstream product

• 67-56-1 methanol 
• 888-60-8 2-phenyl-1H-imidazole-4,5-dicarboxylic acid 
• 586966-04-3 dimethyl (E/Z)-2-(5-phenyltetrazol-1-yl)butenedioate 
• 762-42-5 dimethyl acetylenedicarboxylate 
• 1097966-68-1 5-(methoxycarbonyl)-2-phenyl-1H-imidazole-4-carboxylic acid 
• 154546-41-5 (Z)-2-Benzylamino-but-2-enedioic acid dimethyl ester 
• 100-46-9 benzylamine 

Downstream Products

• 117120-97-5 dimethyl 1-methyl-2-phenyl-1H-imidazole-4,5-dicarboxylate 
• 117121-04-7 (5-Hydroxymethyl-3-methyl-2-phenyl-3H-imidazol-4-yl)-methanol 
• 117120-87-3 Methyl-carbamic acid 3-methyl-5-methylcarbamoyloxymethyl-2-phenyl-3H-imidazol-4-ylmethyl ester 
• 851772-88-8 C₁₃H₁₃N₃O₄ 

Relevant articles and documents

Photocatalytic Visible-Light-Induced Nitrogen Insertion via Dual C(sp3)-H and C(sp2)-H Bond Functionalization: Access to Privileged Imidazole-based Scaffolds

Here we have demonstrated a visible-light-mediated metal-free organic-dye-catalyzed dehydrogenative N-insertion leading to highly substituted imidazoles and privileged dihydroisoquinoline-based imidazole derivatives via C(sp3)-H and C(sp2)-H bond functionalization. A sustainable, convenient, metal-free azidation/C-H aminative cyclization approach in the absence of stoichiometric oxidants is presented. This protocol involves a rare photoinduced iminyl radical as a key intermediate for the "N"insertion.

PHENYL-ANILINE SUBSTITUTED BICYCLIC COMPOUNDS USEFUL AS KINASE INHIBITORS

Compounds having the formula (I), and pharmaceutically acceptable salts, prodrugs, and solvates thereof, are useful as kinase inhibitors, wherein R, R1 , R2, R5, R6a, R6b, J, K, X and Z are as described in the specification.

Design, Synthesis, Antineoplastic Activity, and Chemical Properties of Bis(carbamate) Derivatives of 4,5-Bis(hydroxymethyl)imidazole

A series of bis(carbamate) derivatives of 1,2-substituted 4,5-bis(hydroxymethyl)imidazoles were prepared and evaluated against murine P388 lymphocytic leukemia.Electron-withdrawing substituents at either N-1 or C-2 gave rise to inactive compounds.However, electron-donating substituents gave active compounds and the 2-(methylthio)-1-methyl derivative 2i (carmethizole), as the bis(N-methylcarbamate), was found to be very active.The derivative 2i, referred to by the name carmethizole, was also shown to be active against the MX-1 mammary xenograft, the human amelanotic melanoma cell line (LOX) xenograft, the M5076 sarcoma, and L1210 lymphocytic leukemia.The solution stability, water solubility, pKa, and log P of carmethizole are also reported.