521917-51-1

Basic information

• Product Name: 1,2-DIHYDRO-NAPHTHALENE-3-BORONIC ACID
• Synonyms: 1,2-DIHYDRO-NAPHTHALENE-3-BORONIC ACID;(3,4-Dihydronaphthalen-2-yl)boronic acid
• CAS NO: 521917-51-1
• Molecular Formula: C10H11BO2
• Molecular Weight: 174
• Mol File: 521917-51-1.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 353.1±52.0 °C(Predicted)
• Appearance: /
• Density: 1.18±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 9.63±0.20(Predicted)
• CAS DataBase Reference: 1,2-DIHYDRO-NAPHTHALENE-3-BORONIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-DIHYDRO-NAPHTHALENE-3-BORONIC ACID(521917-51-1)
• EPA Substance Registry System: 1,2-DIHYDRO-NAPHTHALENE-3-BORONIC ACID(521917-51-1)

Safety Data

• Hazardous Substances Data: 521917-51-1(Hazardous Substances Data)

Usage

General Description

1,2-Dihydro-naphthalene-3-boronic acid is a chemical compound with the molecular formula C12H13BO2. It is a boronic acid derivative of naphthalene, a polycyclic aromatic hydrocarbon. 1,2-DIHYDRO-NAPHTHALENE-3-BORONIC ACID is commonly used in organic synthesis as a building block for various pharmaceutical and agrochemical compounds. It is also used in the synthesis of fluorescent dyes and materials for organic electronics. The boronic acid group in this compound can form reversible covalent bonds with diols and other nucleophiles, making it a versatile reactant in various chemical reactions. Additionally, it is a valuable tool in the field of medicinal chemistry for the development of new drugs and pharmaceuticals.

Upstream product

• 92013-27-9 3-bromo-1,2-dihydroxynaphthalene 
• 1056246-70-8 2-bromo-1-tetralone 
• 64245-04-1 2-bromo-1-hydroxy-1,2,3,4-tetrahydronaphthalene 
• 529-34-0 3,4-dihydronaphthalene-1(2H)-one 
• 5419-55-6 Triisopropyl borate 

Relevant articles and documents

Azologization and repurposing of a hetero-stilbene-based kinase inhibitor: Towards the design of photoswitchable sirtuin inhibitors

The use of light as an external trigger to change ligand shape and as a result its bioactivity, allows the probing of pharmacologically relevant systems with spatiotemporal resolution. A hetero-stilbene lead resulting from the screening of a compound that was originally designed as kinase inhibitor served as a starting point for the design of photoswitchable sirtuin inhibitors. Because the original stilbenoid structure exerted unfavourable photochemical characteristics it was remodelled to its heteroarylic diazeno analogue. By this intramolecular azologization, the shape of the molecule was left unaltered, whereas the photoswitching ability was improved. As anticipated, the highly analogous compound showed similar activity in its thermodynamically stable stretched-out (E)-form. Irradiation of this isomer triggers isomerisation to the long-lived (Z)-configuration with a bent geometry causing a considerably shorter end‐to‐end distance. The resulting affinity shifts are intended to enable real‐time photomodulation of sirtuins in vitro.

Substituted imidazol-pyridazine derivatives

The present invention relates to compounds of formula wherein A is an unsubstituted or substituted cyclic group; and R is hydrogen or lower alkyl; or a pharmaceutically acceptable acid addition salt thereof. These compounds are NMDA NR-2B receptor subtype specific blockers and are useful in the treatment of neurodegeneration, depression and pain.