5221-17-0Relevant articles and documents
Enantioselective synthesis of trans-fused bicyclo[5.3.0]decane systems via a tandem [4+3] cycloaddition-Nicholas reaction
Montana, Angel M.,Fernandez, David
, p. 6499 - 6502 (1999)
An enantioselective synthetic methodology to prepare trans-fused bicyclo[5.3.0]decane systems is presented. It is a very versatile methodology based on two key reactions: [4+3] cycloaddition reaction (to generate the seven-membered ring) and the Nicholas reaction (that facilitates the insertion of the five-membered ring). This methodology allows the easy preparation of a wide range of bioactive natural products containing the transfused bicyclo[5.3.0]decane system. The application of this methodology to the enantioselective synthetic approach to the pseudoguaiane carbon- skeleton is described.
Method for synthesizing bis(2-methyl-3-furyl) disulfide
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Paragraph 0057-0060; 0081-0088; 0115-0118; 0139-0142, (2017/07/19)
The invention relates to a method for synthesizing bis(2-methyl-3-furyl) disulfide. The method comprises the following steps: (1) enabling acrolein to react with bromine to obtain a product 1; (2) adding the product 1 into an absolute ethyl alcohol solution of sodium hydroxide to prepare propiolaldehyde diethyl acetal; (3) enabling ethyl ether and bromoethane to react with chloroethane in presence of magnesium, then adding mixed liquid of the propiolaldehyde diethyl acetal and the ethyl ether and subsequently adding mixed liquid of acetaldehyde and ethyl ether for carrying out a reaction, and hydrolyzing to prepare 4-hydroxy-2-pentyne propanal diethyl acetal; (4) adding the 4-hydroxy-2-pentyne propanal diethyl acetal into a water solution containing sulfuric acid, pentane and potassium thiocyanate to prepare a product 4; (5) adding the product 4 into a sodium hydroxide water solution to prepare the bis(2-methyl-3-furyl) disulfide. Compared with the existing synthesis method, the method provided by the invention is easy in control of reaction conditions, fewer in side reactions, easy in control of intermediate products and higher in yield of a target product, thus having wide application prospect.
Propynal equivalents and diazopropyne: Synthesis of all mono-13C isotopomers
Seburg, Randal A.,Hodges, Jonathan A.,McMahon, Robert J.
experimental part, p. 1626 - 1643 (2009/10/17)
Mechanistic and spectroscopic investigations of reactive C 3H2 hydrocarbons necessitated the preparation of diazopropyne isotopomers bearing mono-13C substitution at each of the three unique positions. The diazo compounds and their tosylhydrazone precursors were prepared from the mono-13C isotopomers of propynal (in the form of either the aldehyde or the diethyl acetal). The introduction of 13C-labeling at either alkyne position in propynal utilized the Corey - Fuchs procedure for chain homologation.