52240-10-5

Basic information

• Product Name: Benzonitrile, 4-(1,6-dihydro-6-oxo-3-pyridazinyl)-
• CAS NO: 52240-10-5
• Molecular Formula: C11H7N3O
• Molecular Weight: 197.196
• Mol File: 52240-10-5.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: Benzonitrile, 4-(1,6-dihydro-6-oxo-3-pyridazinyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzonitrile, 4-(1,6-dihydro-6-oxo-3-pyridazinyl)-(52240-10-5)
• EPA Substance Registry System: Benzonitrile, 4-(1,6-dihydro-6-oxo-3-pyridazinyl)-(52240-10-5)

Safety Data

• Hazardous Substances Data: 52240-10-5(Hazardous Substances Data)

Upstream product

• 36725-37-8 6-(4-bromophenyl)-4,5-dihydropyridazin-3(2H)-one 
• 50636-57-2 6-(4-bromophenyl)-3(2H)-pyridazin-3-one 
• 36725-21-0 4-(6-oxo-1,4,5,6-tetrahydropyridazin-3-yl)benzonitrile 
• 1443-80-7 4-cyanophenyl methyl ketone 
• 298-12-4 Glyoxilic acid 

Downstream Products

• 1087379-64-3 ethyl {3-[6-oxo-3-(4-cyanophenyl)-6H-pyridazin-1-ylmethyl]phenyl}carbamate 
• 1087379-79-0 N-hydroxy-4-(6-oxo-1,6-dihydropyridazin-3-yl)benzamidine 
• 67820-75-1 N'-[6-(4-cyano-phenyl)-pyridazin-3-yl]-hydrazinecarboxylic acid ethyl ester 
• 67821-02-7 4-[4-methyl-6-(N-methyl-hydrazino)-pyridazin-3-yl]-benzonitrile 
• 67820-85-3 N'-[6-(4-cyano-phenyl)-5-methyl-pyridazin-3-yl]-hydrazinecarboxylic acid tert-butyl ester 
• 66548-54-7 3-chloro-6-(4-cyano-phenyl)-pyridazine 
• 832735-48-5 2-(1-t-butoxycarbonylpiperidin-4-yloxy)-5-(4-cyanophenyl)pyridazine 

Relevant articles and documents

Synthesis and Bioevaluation of 3,6-Diaryl-[1,2,4]triazolo[4,3-b] Pyridazines as Antitubulin Agents

A series of 3,6-diaryl-[1,2,4]triazolo[4,3-b]pyridazines were designed as a class of vinylogous CA-4 analogues. The easily isomerized (Z,E)-butadiene linker of vinylogous CA-4 was replaced by a rigid [1,2,4]triazolo[4,3-b]pyridazine scaffold. Twenty-one target compounds were synthesized and exhibited moderate to potent antiproliferative activity. The compound 4q with a 3-amino-4-methoxyphenyl moiety as the B-ring, comparable to CA-4 (IC50 = 0.009-0.012 μM), displayed the highly active antiproliferative activity against SGC-7901, A549, and HT-1080 cell lines with IC50 values of 0.014, 0.008, and 0.012 μM, respectively. Tubulin polymerization experiments indicated that 4q effectively inhibited tubulin polymerization, and immunostaining assay revealed that 4q significantly disrupted tubulin microtubule dynamics. Moreover, cell cycle studies revealed that compound 4q dramatically arrested cell cycle progression at G2/M phase in A549 cells. Molecular modeling studies showed that 4q could bind to the colchicine binding site on microtubules.

PYRIDAZINONE DERIVATIVES

Compounds of the formula (I), in which R1, R2, R3, W and D have the meanings indicated in Claim 1, are inhibitors of tyrosine kinases, in particular of Met kinase, and can be employed, inter alia, for the treatment of tumours.

Heterobiarly derivatives and pharmaceutical compositions thereof

Heterobiaryl derivatives of the formula wherein R1, X1 to X3 and Y1 to Y4 are as defined herein, the tautomers, stereoisomers and mixtures thereof, and the salts, particularly the physiologica