52258-06-7

Basic information

• Product Name: 6-chlorodibenzo[d,f][1,3,2]dioxaphosphepine 6-oxide
• Synonyms: Dibenzo(d,f)(1,3,2)dioxaphosphepin, 6-chloro-, 6-oxide; dibenzo[d,f][1,3,2]dioxaphosphepin, 6-chloro-, 6-oxide
• CAS NO: 52258-06-7
• Molecular Formula: C₁₂H₈ClO₃P
• Molecular Weight: 266.6169
• Mol File: 52258-06-7.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 396.1°C at 760 mmHg
• Flash Point: 298.4°C
• Density: 1.47g/cm³
• Vapor Pressure: 4E-06mmHg at 25°C
• Refractive Index: 1.632
• CAS DataBase Reference: 6-chlorodibenzo[d,f][1,3,2]dioxaphosphepine 6-oxide(CAS DataBase Reference)
• NIST Chemistry Reference: 6-chlorodibenzo[d,f][1,3,2]dioxaphosphepine 6-oxide(52258-06-7)
• EPA Substance Registry System: 6-chlorodibenzo[d,f][1,3,2]dioxaphosphepine 6-oxide(52258-06-7)

Safety Data

• Hazardous Substances Data: 52258-06-7(Hazardous Substances Data)

Upstream product

• 1806-29-7 2,2'-dihydroxybiphenyl 

Downstream Products

• 35227-84-0 1,1'-biphenyl-2,2'-diyl hydrogen phosphate 
• 105053-46-1 6-phenoxydibenzo(1,3,2)-dioxaphosphepin 6-oxide 

Relevant articles and documents

Phosphorus containing heterocycles as fungicides: synthesis of 2,2' diphenylene chlorophosphonate and 2,2' diphenylene chlorothiophosphonate

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Polyethers with phosphate pendant groups by monomer activated anionic ring opening polymerization: Syntheses, characterization and their lithium-ion conductivities

This paper describes the preparations and lithium-ion conductivities of various solid polymer electrolytes for potential use in high-energy density lithium-ion batteries. The ring opening polymerization of epoxides (M1-M6), catalyzed by Zn(II), Cu(II) and Cd(II) complexes in the presence of tetrabutylammonium bromide (TBAB), yielded polyethers (P1-P6) in which phosphates were attached as pendant groups. A reaction condition where Zn(II) catalyst used slightly excess to TBAB increased the polymerization rate remarkably and yielded the polyethers with higher molar masses in a short time. These polymerizations proceeded following a "monomer activated anionic ring opening polymerization" mechanism. These living like polymerizations also progressed according to "formation of polymer chain per initiator" model. The solid-state lithium-ion conductivities of these polymers were examined using lithium bis(trifluoromethanesulfonyl)imide (LiTFSI). The conductivity of one of the solid polymer electrolytes with 40 wt% of LiTFSI was 5.2 × 10-5 S cm-1 at room temperature and 2.9 × 10-4 S cm-1 at 80 C.

Artemisinin-derived dimer phosphate esters as potent anti-cytomegalovirus (anti-CMV) and anti-cancer agents: A structure-activity study

We recently reported the anti-cancer and anti-cytomegalovirus (CMV) activity of artemisinin-derived trioxane diphenylphosphate dimer 838. To probe the relationship between chemical structure and anti-CMV and anti-cancer activities, we now report synthesis and evaluation of a series of eight new dimer phosphate ester analogs of 838. This series of novel molecules was screened against human foreskin fibroblasts (HFFs) infected with CMV and against the human Jurkat T cell acute lymphoblastic leukemia cell line. This SAR study confirms the very high anti-CMV and anti-cancer potencies of dimer diphenyl phosphate ester 838 without its being toxic to normal cells.