52320-67-9 Usage
Description
N-(2-methyl-1-oxobutyl)-Glycine, also known as 2-Methylbutyrylglycine, is a N-acylglycine derivative where glycine is substituted by a 2-methylbutanoyl group at the N atom. It is an important class of metabolites that have been utilized in the diagnosis of various inborn errors of metabolism (IEM).
Uses
Used in Diagnostic Applications:
N-(2-methyl-1-oxobutyl)-Glycine is used as a diagnostic marker for the detection and identification of several inborn errors of metabolism (IEM). Its presence in biological samples can indicate specific metabolic disorders, aiding in the diagnosis and treatment of these conditions.
Used in Pharmaceutical Industry:
N-(2-methyl-1-oxobutyl)-Glycine is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique chemical structure allows for the development of new drugs targeting specific metabolic pathways, potentially leading to novel treatments for a range of diseases.
Used in Research and Development:
In the field of research and development, N-(2-methyl-1-oxobutyl)-Glycine serves as a valuable tool for studying the underlying mechanisms of inborn errors of metabolism. This knowledge can contribute to the advancement of medical science and the development of targeted therapies for these conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 52320-67-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,2,3,2 and 0 respectively; the second part has 2 digits, 6 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 52320-67:
(7*5)+(6*2)+(5*3)+(4*2)+(3*0)+(2*6)+(1*7)=89
89 % 10 = 9
So 52320-67-9 is a valid CAS Registry Number.
InChI:InChI=1/C7H13NO3/c1-3-5(2)7(11)8-4-6(9)10/h5H,3-4H2,1-2H3,(H,8,11)(H,9,10)
52320-67-9Relevant articles and documents
Repurposing the 3-Isocyanobutanoic Acid Adenylation Enzyme SfaB for Versatile Amidation and Thioesterification
Zhu, Mengyi,Wang, Lijuan,He, Jing
supporting information, p. 2030 - 2035 (2020/11/30)
Genome mining of microbial natural products enables chemists not only to discover the bioactive molecules with novel skeletons, but also to identify the enzymes that catalyze diverse chemical reactions. Exploring the substrate promiscuity and catalytic mechanism of those biosynthetic enzymes facilitates the development of potential biocatalysts. SfaB is an acyl adenylate-forming enzyme that adenylates a unique building block, 3-isocyanobutanoic acid, in the biosynthetic pathway of the diisonitrile natural product SF2768 produced by Streptomyces thioluteus, and this AMP-ligase was demonstrated to accept a broad range of short-chain fatty acids (SCFAs). Herein, we repurpose SfaB to catalyze amidation or thioesterification between those SCFAs and various amine or thiol nucleophiles, thereby providing an alternative enzymatic approach to prepare the corresponding amides and thioesters in vitro.
