52377-28-3

Basic information

• Product Name: 1,8-NAPHTHYRIDINE-3-CARBONYL CHLORIDE,1-ETHYL-1,4-DIHYDRO-7-METHYL-4-OXO
• Synonyms: 1,8-NAPHTHYRIDINE-3-CARBONYL CHLORIDE,1-ETHYL-1,4-DIHYDRO-7-METHYL-4-OXO;1-ethyl-1,4-dihydro-7-methyl-4-oxo-1,8-naphthyridine-3-carbonyl chloride;1-Ethyl-7-methyl-4-oxo-1,8-naphthyridine-3-carbonyl chloride
• CAS NO: 52377-28-3
• Molecular Formula: C₁₂H₁₁ClN₂O₂
• Molecular Weight: 250.69
• Mol File: 52377-28-3.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1,8-NAPHTHYRIDINE-3-CARBONYL CHLORIDE,1-ETHYL-1,4-DIHYDRO-7-METHYL-4-OXO(CAS DataBase Reference)
• NIST Chemistry Reference: 1,8-NAPHTHYRIDINE-3-CARBONYL CHLORIDE,1-ETHYL-1,4-DIHYDRO-7-METHYL-4-OXO(52377-28-3)
• EPA Substance Registry System: 1,8-NAPHTHYRIDINE-3-CARBONYL CHLORIDE,1-ETHYL-1,4-DIHYDRO-7-METHYL-4-OXO(52377-28-3)

Safety Data

• Hazardous Substances Data: 52377-28-3(Hazardous Substances Data)

Usage

General Description

1,8-naphthyridine-3-carbonyl chloride is a chemical compound with the molecular formula C13H8ClNO that is used in the production of pharmaceuticals. It is a white solid with a strong odor and is reactive with water and air. 1-ethyl-1,4-dihydro-7-methyl-4-oxo is a chemical compound with the molecular formula C8H13NO that is commonly used as a precursor in the synthesis of pharmaceuticals and other organic compounds. It is a colorless liquid with a strong odor and is highly flammable. These chemicals are both important intermediates in the production of various pharmaceuticals and organic compounds, and their reactivity and properties make them crucial in the synthesis of many products.

Upstream product

• 389-08-2 nalidixic Acid 
• 33331-59-8 ethyl 1-ethyl-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate 

Downstream Products

• 1352786-64-1 1-ethyl-7-methyl-3-(3-phenylprop-2-ynoyl)-1,4-dihydro-1,8-naphthyridin-4-one 

Relevant articles and documents

Synthesis and inverse virtual screening of new bi-cyclic structures towards cancer-relevant cellular targets

We report here synthetic approaches to access new classes of small molecules based on three heterocyclic scaffolds, i.e. 3,7-dihydropyrimido[4,5-d]pyridazine-4,8-dione, 1,8-naphthyridin-4(1H)-one and 4H-pyrido[1,2-a]pyrimidin-4-one. The bi-cyclic structure 3,7-dihydropyrimido[4,5-d]pyridazine-4,8-dione is a new heterocycle, described here for the first time. In silico methodologies of inverse virtual screening have been used to preliminary analyse the molecules, in order to explore their potential as hits for chemical biology investigations. Our computational study has been conducted with 43 synthetically accessible small molecules towards 31 cellular proteins involved in cancer pathogenesis. Binding energies were quantified using molecular docking calculations, allowing to define the relative affinities of the ligands for the cellular targets. Through this methodology, 16 proteins displayed effective interactions with distinct small molecules within the matrix. In addition, 23 ligands have demonstrated high affinity for at least one cellular protein, using as reference the co-crystallised ligand in the X-ray structure. The evaluation of ADME and drug score for selected hits also highlights that these new molecular series can serve as sources of lead candidates for further structure optimisation and biological studies.

Design, synthesis, and antitubercular evaluation of novel series of 3-benzofuran-5-aryl-1-pyrazolyl-pyridylmethanone and 3-benzofuran-5-aryl-1- pyrazolylcarbonyl-4-oxo-naphthyridin analogs

Twenty-eight newer 3-benzofuran-5-aryl-1-pyrazolyl-pyridylmethanone and 3-benzofuran-5-aryl-1-pyrazolylcarbonyl-4-oxo-naphthyridin analogs were synthesized by microwave irradiation method and evaluated for in-vitro and in-vivo antitubercular activity agai

Nalidixic acid prodrugs: Amides from amino acid esters and nalidixic acid

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