52407-60-0

Basic information

• Product Name: N-(p-AMinobenzoyl)-L-glutaMic Acid DiMethyl Ester
• Synonyms: N-(p-AMinobenzoyl)-L-glutaMic Acid DiMethyl Ester
• CAS NO: 52407-60-0
• Molecular Formula: C₁₄H₁₈N₂O₅
• Molecular Weight: 294.30312
• Product Categories: Amino Acids & Derivatives, Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 52407-60-0.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 505.6±50.0 °C(Predicted)
• Appearance: /
• Density: 1.234±0.06 g/cm3(Predicted)
• Solubility: DMSO. Methanol
• PKA: 13.66±0.46(Predicted)
• CAS DataBase Reference: N-(p-AMinobenzoyl)-L-glutaMic Acid DiMethyl Ester(CAS DataBase Reference)
• NIST Chemistry Reference: N-(p-AMinobenzoyl)-L-glutaMic Acid DiMethyl Ester(52407-60-0)
• EPA Substance Registry System: N-(p-AMinobenzoyl)-L-glutaMic Acid DiMethyl Ester(52407-60-0)

Safety Data

• Hazardous Substances Data: 52407-60-0(Hazardous Substances Data)

Usage

Description

N-(p-Aminobenzoyl)-L-glutamic Acid Dimethyl Ester is an organic compound that serves as a crucial intermediate in the synthesis of Folic Acid, a vital vitamin essential for various biological processes.

Uses

Used in Pharmaceutical Industry:
N-(p-Aminobenzoyl)-L-glutamic Acid Dimethyl Ester is used as an intermediate in the synthesis of Folic Acid (F680300) for its role in DNA synthesis, DNA repair, and DNA methylation. Acting as a cofactor in biological reactions involving folate, it contributes to the production of new cells and the maintenance of overall cellular health.

Upstream product

• 6525-53-7 glutamic acid dimethyl ether 
• 150-13-0 4-amino-benzoic acid 
• 617-65-2 Glutamic acid 
• 66493-39-8 4-(N-tert-butoxycarbonyl)aminobenzoic acid 
• 321527-88-2 tert-Butyl [4-(chlorocarbonyl)phenyl]carbamate 
• 67-56-1 methanol 
• 4271-30-1 N-(4-aminobenzoyl)-L-glutamic acid 
• 218603-08-8 dimethyl N-<4-benzoyl>-L-glutamate 
• 185116-43-2 4-(9H-fluoren-9-ylmethoxycarbonylamino)benzoic acid 

Downstream Products

• 67726-14-1 N-{4-[(2-oxo-benzooxazol-3-ylmethyl)-amino]-benzoyl}-glutamic acid dimethyl ester 
• 67726-20-9 N-{4-[(2-thioxo-benzooxazol-3-ylmethyl)-amino]-benzoyl}-glutamic acid dimethyl ester 
• 67726-26-5 N-{4-[(2-thioxo-benzothiazol-3-ylmethyl)-amino]-benzoyl}-glutamic acid dimethyl ester 
• 72730-50-8 N-{4-[(5-methoxycarbonyl-2-thioxo-benzooxazol-3-ylmethyl)-amino]-benzoyl}-glutamic acid dimethyl ester 
• 129082-61-7 dimethyl N<4-<2-(2,4-bis(acetylamino)-1,6-dihydro-6-oxo-5-pyrimidinyl)ethyl-N-methylamino>benzoyl>-L-glutamate 
• 87373-68-0 (S)-2-{4-[(2,4-Diamino-pyrido[2,3-d]pyrimidin-6-ylmethyl)-amino]-benzoylamino}-pentanedioic acid dimethyl ester 
• 129082-60-6 dimethyl N-<4-<2-(2-acetylamino-4-diacetylamino-1,6-dihydro-6-oxo-5-pyrimidinyl)ethylamino>benzoyl>-L-glutamate 
• 76282-79-6 N^2'-acetyl-5-deaza-7-L-<<<4-<<<1,3-bis(methoxycarbonyl)propyl>amino>carbonyl>phenyl>imino>methyl>pterin 
• 72244-64-5 dimethyl N-(3,5-dichloro-4-aminobenzoyl)-L-glutamate 
• 87373-68-0 2-{4-[(2,4-Diamino-pyrido[2,3-d]pyrimidin-6-ylmethyl)-amino]-benzoylamino}-pentanedioic acid dimethyl ester 
• 87373-57-7 2-(4-{[1-(2-Acetylamino-4-oxo-3,4-dihydro-pyrido[2,3-d]pyrimidin-6-yl)-meth-(Z)-ylidene]-amino}-benzoylamino)-pentanedioic acid dimethyl ester 
• 118869-56-0 dimethyl N-<4-<<(2-amino-3-cyanopyrazin-5-yl)methyl>amino>benzoyl>-L-glutamate 
• 161201-03-2 dimethyl N-<4-<<(2,4-diaminoquinazolin-5-yl)methyl>amino>benzoyl>-L-glutamate 
• 218603-30-6 N-<4-carbonyl>pyridin-2-ylmethyl)>aminobenzoyl>-L-glutamate 

Relevant articles and documents

Diastereoselective hydrogenation of folic acid esters with the Daniphos ligand

Folic acid dimethylester benzenesulfonate was hydrogenated homogeneously in a rhodium-catalyzed diastereoselective reaction employing a set of the previously published planar-chiral "Daniphos" ligands, which are based on an arene chromium tricarbonyl scaf

The Synthesis and Preferred Conformation of Pyridoyl Urea and Analogous Derivatives. Preparation of a Folate Analogue

The synthesis of 2-pyridoyl urea and analogous derivatives is reported. Also the synthesis of a folate analogue, containing 2-pyridoyl urea instead of the pterine moiety, is described. NMR Spectra show that the acylureas adopt an intramolecular H-bonded c