52421-75-7

Basic information

• Product Name: 4-ETHYL-6-HYDROXY-2-METHYLPYRIMIDINE
• Synonyms: 4-ETHYL-6-HYDROXY-2-METHYLPYRIMIDINE;6-ETHYL-2-METHYLPYRIMIDIN-4-OL;4(1H)-Pyrimidinone, 6-ethyl-2-methyl- (9CI);4-Ethyl-6-hydroxy-2-methylpyrimidine ,97%
• CAS NO: 52421-75-7
• Molecular Formula: C₇H₁₀N₂O
• Molecular Weight: 138.17
• Product Categories: PYRIMIDINE;Heterocycle-Pyrimidine series
• Mol File: 52421-75-7.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 249.3 °C at 760 mmHg
• Flash Point: 104.5 °C
• Appearance: /
• Density: 1.119 g/cm³
• Vapor Pressure: 0.0147mmHg at 25°C
• Refractive Index: 1.539
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 4-ETHYL-6-HYDROXY-2-METHYLPYRIMIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-ETHYL-6-HYDROXY-2-METHYLPYRIMIDINE(52421-75-7)
• EPA Substance Registry System: 4-ETHYL-6-HYDROXY-2-METHYLPYRIMIDINE(52421-75-7)

Safety Data

• Safety Statements: 24/25
• Hazardous Substances Data: 52421-75-7(Hazardous Substances Data)

Usage

Chemical Properties

Off-white solid

InChI:InChI=1/C7H10N2O/c1-3-6-4-7(10)9-5(2)8-6/h4H,3H2,1-2H3,(H,8,9,10)

Upstream product

• 883528-73-2 3-amino-4-methyl crotonic acid methylester 
• 71-36-3 butan-1-ol 
• 124-42-5 acetamidine hydrochloride 
• 4949-44-4 ethyl propanoylacetate 
• 95395-76-9 3-amino-2-pentenamide 
• 74372-16-0 propionylacetamide 
• 72324-46-0 6-ethyl-2,2-dimethyl-2H,4H-1,3-dioxin-4-one 
• 95395-82-7 3-acetamido-2-pentenamide 
• 30414-53-0 methyl propanoyl acetate 

Downstream Products

• 82236-25-7 4-(1-chloroethyl)-2-methyl-6-phenylpyrimidine 
• 89966-73-4 4-ethyl-2-methyl-6-phenylpyrimidine 
• 89966-77-8 6-ethyl-2-methyl-4-phenylpyrimidine 1-oxide 

Relevant articles and documents

SUBSTITUTED TETRAHYDROQUINOLINONE COMPOUNDS AS ROR GAMMA MODULATORS

The present invention provides substituted tetrahydroquinolinone and related compounds of formula (I), which are therapeutically useful as modulators of Retinoic acid receptor-related orphan receptors (RORs), more particularly as RORγ modulators. These co

Synthesis of β-Ketocarboxamide Derivatives Using 2,2-Dimethyl-2H,4H-1,3-dioxin-4-ones

Thermal reaction of 2,2-dimethyl-2H,4H-1,3-dioxin-4-ones (1) with amines was studied.Acylketenes 2, generated by heating of 1, reacted with anilines and benzylamine to give the corresponding β-ketocarboxamides (3,4, and 5) in good yields.The reaction of 1 with ammonia gave 3-amino-2-alkenamides (7), which were hydrolyzed to β-ketocarboxamides (6).The former products 7 were readily transformed to the 6-substituted 2-methyl-3H-pyrimidin-4-ones (9) via the 3-acetamido-2-alkenamides (8).Acylation of O-benzylhydroxylamine with 1 gave the β-ketohydroxamic acids 10.Debenzylation of 10 followed by cyclization gave rise to 5-alkyl-3-hydroxyisoxazoles (12).The reaction of 1 with amides gave the corresponding N-acetylated amides (13). Keywords --- 2H,4H-1,3-dioxin-4-one; thermal fragmentation; acylketene; acylation; carboxamide; hydroxamic acid; 3-hydroxyisoxazole; 3H-pyrimidin-4-one