524734-89-2

Basic information

• Product Name: 1-methyl-4-nitro-1H-pyrrole-2-carboxylic acid {4-[bis-(2-hydroxy-ethyl)-amino]-phenyl}-amide
• CAS NO: 524734-89-2
• Molecular Weight: 348.359
• Mol File: 524734-89-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-methyl-4-nitro-1H-pyrrole-2-carboxylic acid {4-[bis-(2-hydroxy-ethyl)-amino]-phenyl}-amide(CAS DataBase Reference)
• NIST Chemistry Reference: 1-methyl-4-nitro-1H-pyrrole-2-carboxylic acid {4-[bis-(2-hydroxy-ethyl)-amino]-phenyl}-amide(524734-89-2)
• EPA Substance Registry System: 1-methyl-4-nitro-1H-pyrrole-2-carboxylic acid {4-[bis-(2-hydroxy-ethyl)-amino]-phenyl}-amide(524734-89-2)

Safety Data

• Hazardous Substances Data: 524734-89-2(Hazardous Substances Data)

Upstream product

• 13138-78-8 1-methyl-4-nitro-pyrrol-2-carboxylic acid 
• 7575-35-1 N,N-bis(2-hydroxyethyl)-4-aminoaniline 

Downstream Products

• 524734-94-9 1-methyl-4-nitro-1H-pyrrole-2-carboxylic acid {4-[bis-(2-chloro-ethyl)-amino]-phenyl}-amide 
• 524734-95-0 4-amino-1-methyl-1H-pyrrole-2-carboxylic acid {4-[bis-(2-chloro-ethyl)-amino]-phenyl}-amide 
• 524734-92-7 methanesulfonic acid 2-((2-methanesulfonyloxy-ethyl)-{4-[(1-methyl-4-nitro-1H-pyrrole-2-carbonyl)-amino]-phenyl}-amino)-ethyl ester 

Relevant articles and documents

Synthesis and preliminary cytotoxicity of nitrogen mustard derivatives of distamycin A

Distamycin and nitrogen mustard conjugates, in which the nitrogen mustard unit was coupled to the C-terminus of the pyrrole, were synthesized. The switching of the nitrogen mustard unit from the N-terminus to the C-terminus did not compromise the compound's cytotoxicity. Compound 3, bearing three pyrrole units, was highly toxic to human K562 leukemia cells in vitro with an IC50 value of 0.03 μM. Addition of a trans double bond to the molecule had little effects on cytotoxicity.