52492-69-0

Basic information

• Product Name: 4-(dodecylamino)-4-oxoisocrotonic acid
• Synonyms: 4-(dodecylamino)-4-oxoisocrotonic acid;dodecylmaleamic acid;(Z)-4-Oxo-4-(dodecylamino)-2-butenoic acid;N-Dodecylmaleamidic acid;Einecs 257-960-0;Nsc 68846
• CAS NO: 52492-69-0
• Molecular Formula: C₁₆H₂₉NO₃
• Molecular Weight: 283.40636
• EINECS: 257-960-0
• Mol File: 52492-69-0.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 463.4°Cat760mmHg
• Flash Point: 234°C
• Appearance: /
• Density: 0.988g/cm³
• Vapor Pressure: 7.16E-10mmHg at 25°C
• Refractive Index: 1.479
• CAS DataBase Reference: 4-(dodecylamino)-4-oxoisocrotonic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(dodecylamino)-4-oxoisocrotonic acid(52492-69-0)
• EPA Substance Registry System: 4-(dodecylamino)-4-oxoisocrotonic acid(52492-69-0)

Safety Data

• Hazardous Substances Data: 52492-69-0(Hazardous Substances Data)

Usage

General Description

4-(dodecylamino)-4-oxoisocrotonic acid is a chemical compound that belongs to the family of isocrotonic acids. It is made up of a dodecylamino group attached to a 4-oxoisocrotonic acid molecule, which is a derivative of crotonic acid. 4-(dodecylamino)-4-oxoisocrotonic acid is used in the synthesis of various organic compounds and is also a key ingredient in the production of certain pharmaceuticals and agrochemicals. It has a wide range of industrial applications, including its use as a surfactant, dispersing agent, and emulsifier in various products. Additionally, it is known for its ability to function as a chelating agent, making it useful in various chemical and industrial processes. Overall, 4-(dodecylamino)-4-oxoisocrotonic acid is a versatile compound that plays a crucial role in the manufacturing of various products across different industries.

InChI:InChI=1/C16H29NO3/c1-2-3-4-5-6-7-8-9-10-11-14-17-15(18)12-13-16(19)20/h12-13H,2-11,14H2,1H3,(H,17,18)(H,19,20)/b13-12+

Upstream product

• 108-31-6 maleic anhydride 
• 124-22-1 n-Dodecylamine 
• 110-16-7 maleic acid 

Downstream Products

• 17616-03-4 n-dodecylmaleimide 

Relevant articles and documents

Interfacial properties of novel surfactants based on maleic and succinic acid for potential application in personal care

Hemiesters and Hemiamides of maleic and succinic acid viz. sodium lauryl succinate (C12SE), sodium lauryl maleate (C12ME), sodium lauryl succinamide (C12SA), sodium lauryl maleamide (C12MA), sodium hexadecyl succinate (C16SE) and sodium hexadecyl maleate (C16ME) were synthesized and investigated as surfactants in the pure water and aqueous hydrotrope [sodium p-toluene sulfonate (NaPTs)] solution. The chemical structures of the prepared surfactants were established by FTIR and 1H NMR spectroscopy. The surface tension measurements depicted low CMC and a high adsorption efficiency (pC20) which is highly beneficial for creating personal care formulations. The dynamic light scattering (DLS) technique indicated the formation of larger micelles which was important for skin care as larger micelles cannot penetrate the skin layer. Moreover, these surfactants depicted good foamability and stability attributed to faster monomer adsorption and small bubble size which was preferred for cleansing application. Additionally, low protein/lipid solubilization by these surfactants indicated its mild behaviour on skin as compared to other commonly used conventional anionic [sodium lauryl sulfate (SLS)], zwitterionic [cocamidopropyl betaine (CAPB)] and nonionic [decyl glucoside (DG)] surfactants. Viscosity measurements suggested decent thickening ability of surfactants in the presence of co-surfactant like lauramine oxide. Basis of all the properties discussed, these novel hemiesters and hemiamides seem promising as surfactants for improving various characteristics in potential personal care formulations.

Compound, application thereof, platinum coordination complex and liposome thereof

The invention relates to the field of medicines, in particular to a compound, application thereof, a platinum coordination complex and liposome thereof. The platinum coordination complex disclosed by the invention can be well combined with a membrane material of the liposome, so that encapsulation efficiency and drug loading capacity of the liposome are improved; furthermore, the platinum coordination complex disclosed by the invention contains carboxyl and has pH sensitivity; the carboxyl trends to be deprotonated in lower pH value environment (such as tumor tissues), so that release of medicine in the tumor tissues is improved, and a curing effect of medicine is improved. Experiments show that the liposome disclosed by the invention can reduce toxic and side effects of the medicine and improve medicine effects.