52499-94-2 Usage
Description
PENTAMETHYLBENZENESULFONYL CHLORIDE, also known as Tosyl Chloride, is an organic compound with the chemical formula C11H15ClO2S. It is a colorless to pale yellow crystalline solid that is soluble in organic solvents. Tosyl Chloride is a valuable reagent in organic synthesis due to its ability to act as an acylating and tosylating agent.
Uses
Used in Organic Synthesis:
PENTAMETHYLBENZENESULFONYL CHLORIDE is used as a reactant for the preparation of benzosultam derivatives. It is involved in the chlorosulfonylation of benzene derivatives, followed by azide substitution and cobalt-porphyrin-catalyzed amination/cyclization. This process is essential in the synthesis of various organic compounds and pharmaceuticals.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, PENTAMETHYLBENZENESULFONYL CHLORIDE is used as a key intermediate in the synthesis of various drugs and drug candidates. Its ability to act as an acylating and tosylating agent makes it a versatile reagent for the modification of biologically active molecules, enhancing their properties and therapeutic potential.
Used in Chemical Research:
PENTAMETHYLBENZENESULFONYL CHLORIDE is also used in chemical research as a valuable tool for the protection of functional groups, particularly in the synthesis of complex organic molecules. Its selective reactivity and ease of removal make it a preferred choice for protecting specific functional groups during multi-step synthesis processes.
Check Digit Verification of cas no
The CAS Registry Mumber 52499-94-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,2,4,9 and 9 respectively; the second part has 2 digits, 9 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 52499-94:
(7*5)+(6*2)+(5*4)+(4*9)+(3*9)+(2*9)+(1*4)=152
152 % 10 = 2
So 52499-94-2 is a valid CAS Registry Number.
InChI:InChI=1/C11H15ClO2S/c1-6-7(2)9(4)11(15(12,13)14)10(5)8(6)3/h1-5H3
52499-94-2Relevant articles and documents
Paleos et al.
, p. 3594 (1974)
Method for protecting guanidino group and restoring the same
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, (2008/06/13)
A guanidino group in an amino acid or a peptide can be protected with a specific group, i.e. pentamethylbenzensulfonyl, 2,4,6-trimethoxybenzenesulfonyl, 4-methoxy-2,3,5,6-tetramethylbenzenesulfonyl, 4-methoxy-2,6-dimethylbenzenesulfonyl or 4-methoxy-2,3,6-trimethylbenzenesulfonyl, and said group may easily be removed without affecting the amino acid or the peptide to be derived from the protected amino acid or peptide. Thus, the present invention is useful in the synthesis of peptides containing the guanidino group.
