52536-99-9

Basic information

• Product Name: 2-(2-chloroethyl)-1,3-dinitrobenzene
• Synonyms: 2-(2-chloroethyl)-1,3-dinitrobenzene
• CAS NO: 52536-99-9
• Molecular Formula: C₈H₇ClN₂O₄
• Molecular Weight: 230.60518
• Mol File: 52536-99-9.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(2-chloroethyl)-1,3-dinitrobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-chloroethyl)-1,3-dinitrobenzene(52536-99-9)
• EPA Substance Registry System: 2-(2-chloroethyl)-1,3-dinitrobenzene(52536-99-9)

Safety Data

• Hazardous Substances Data: 52536-99-9(Hazardous Substances Data)

Usage

Molecular structure

A benzene ring with two nitro groups (-NO2) and one 2-chloroethyl group (-CH2CH2Cl) attached.

Functional groups

Nitro groups and a 2-chloroethyl group.

Usage

Commonly used as a chemical intermediate in the production of dyes and polymers.

Toxicity

Known for its potential harmful effects on human health and the environment.

Handling and storage

It is important to handle and store 2-(2-chloroethyl)-1,3-dinitrobenzene with caution and in accordance with safety regulations due to its hazardous nature.

Upstream product

• 77759-08-1 2-(2,6-dinitrophenyl)ethanol 
• 606-20-2 2,6-dinitrotoluene 

Downstream Products

• 84807-26-1 4-nitro-2,3-dihydro-1H-indole 
• 4769-97-5 4-nitro-1H-indoIe 

Relevant articles and documents

Synthesis of 2'-deoxyribofuranosyl indole nucleosides related to the antibiotics SF-2140 and neosidomycin

The 2'-deoxyribofuranose analog of the naturally occurring antibiotics SF-2140 and neosidomycin were prepared by the direct glycosylation of the sodium salts of the appropriate indole derivatives, with 1-chloro-2-deoxy-3,5-di-O-p-toluoyl-α-D-erythropentofuranose. Thus, treatment of the sodium salt of 4-methoxy-1H-indol-3-ylacetonitrile with 5 provided the blocked nucleoside, 4-methoxy-1-(2-deoxy-3,5-di-O-p-toluoyl-β-D-erythropentofuranosyl)-1 -indol-3-ylacetonitrile, which was treated with sodium methoxide to yield the SF-2140 analog, 4-methoxy-1-(2-deoxy-β-D-erythropentofuranosyl)-1H-indol-3-ylacetoni rile. The neosidomycin analog was prepared by treatment of the sodium salt of 1H-indol-3-ylacetonitrile with 5 to obtain the blocked intermediate 1-(2-deoxy-3,5-di-O-p-toluoyl-β-D-erythropentofuranosyl)-1H-3-ylacet nitrile followed by sodium methoxide treatment to give 1-(2-deoxy-β-D-erythropentofuranosyl)-1H-indol-3-ylacetonitrile and finally conversion of the nitrile function of 7b to provide 1-(2-deoxy-β-D-erythropentofuranosyl)-1H-indol-3-ylacetamide. In a similar manner, indole and several other substituted indoles including 1H-indole-4-carbonitrile, 4-nitro-1H-indole, 4-chloro-1H-indole-2-carboxamide and 4-chloro-1H-indole-2-carbonitrile were each glycosylated and deprotected to provide 1-(2-deoxy-β-D-erythropentofuranosyl)-1H-indole, 1-(2-deoxy-β-D-erythropentofuranosyl)-1H-indole-4-carbonitrile, 4-nitro-1-(2-deoxy-β-D-erythropentofuranosyl)-1H-indole, 4-chloro-1-(2-deoxy-β-D-erythropentofuranosyl)-1H-indole-2-carboxami e and 4-chloro-1-(2-deoxy-β-D-erythropentofuranosyl)-1H-indole-2-carbonitr le, respectively. The 2'-deoxyadenosine analog in the indole ring system was prepared for the first time by reduction of the nitro group of 11c using palladium on carbon thus providing 4-amino-1-(2-deoxy-β-D-erythropentofuranosyl)-1H-indole (1,3,7-trideaza-2'-deoxyadenosine).