52727-57-8 Usage
Description
Benzoic acid, 2-amino-5-bromo-, methyl ester, also known as Methyl 2-amino-5-bromobenzoate (M2A5B), is a white to light yellow crystal powder with unique chemical properties. It is characterized by its zigzag chains running along the b-axis direction, formed by N-H...O bonds. The nonlinear optical single crystal of M2A5B exhibits good optical transparency and mechanical stability, making it a promising candidate for various applications.
Uses
Used in Pharmaceutical Industry:
Benzoic acid, 2-amino-5-bromo-, methyl ester is used as a potential PqsD inhibitor for combating Pseudomonas aeruginosa infections. It plays a crucial role in inhibiting the growth and progression of this bacterial pathogen, providing a valuable therapeutic option in the fight against resistant infections.
Used in Antiviral Applications:
In the field of antiviral research, Benzoic acid, 2-amino-5-bromo-, methyl ester is utilized in the preparation of hepatitis C virus NS5b RNA polymerase inhibitors. These inhibitors are essential in the development of novel antiviral drugs, targeting the replication process of the hepatitis C virus and potentially leading to more effective treatments.
Used in Agriculture:
Benzoic acid, 2-amino-5-bromo-, methyl ester is involved in plant growth-regulator activity. It is used as a chemical agent to modulate and control plant growth, which can be beneficial in optimizing crop yields and improving overall agricultural productivity.
Synthesis Reference(s)
Tetrahedron Letters, 35, p. 7055, 1994 DOI: 10.1016/0040-4039(94)88224-X
Check Digit Verification of cas no
The CAS Registry Mumber 52727-57-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,2,7,2 and 7 respectively; the second part has 2 digits, 5 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 52727-57:
(7*5)+(6*2)+(5*7)+(4*2)+(3*7)+(2*5)+(1*7)=128
128 % 10 = 8
So 52727-57-8 is a valid CAS Registry Number.
InChI:InChI=1/C8H8BrNO2/c1-12-8(11)6-4-5(9)2-3-7(6)10/h2-4H,10H2,1H3
52727-57-8Relevant articles and documents
INHIBITORS OF ENCEPHALITIC ALPHAVIRUSES
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Page/Page column 156-157, (2021/03/13)
Compounds of Formula I and Formula II: pharmaceutical compositions containing them, and use of the compounds as active ingredients to treat infection with alphavirus.
Imidazo[1,5-a]quinazoline-5(4H)-ketone derivative as well as preparation method and application thereof
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Paragraph 0158-0163, (2020/08/22)
The invention relates to an imidazo[1,5-a]quinazoline-5(4H)-ketone derivative as well as a preparation method and application thereof. The imidazo[1,5-a]quinazoline-5(4H)-ketone derivative disclosed by the invention can be used for preparing a BET protein
Scaffold Hopping of Natural Product Evodiamine: Discovery of a Novel Antitumor Scaffold with Excellent Potency against Colon Cancer
Wang, Lei,Fang, Kun,Cheng, Junfei,Li, Yu,Huang, Yahui,Chen, Shuqiang,Dong, Guoqiang,Wu, Shanchao,Sheng, Chunquan
, p. 696 - 713 (2020/02/04)
Inspired by the natural product evodiamine, a novel antitumor indolopyrazinoquinazolinone scaffold was designed by scaffold hopping. Structure-activity relationship studies led to the discovery of compound 15j, which shows low nanomolar inhibitory activity against the HCT116 cell line. Further antitumor mechanism studies indicated that compound 15j acted by the dual inhibition of topoisomerase 1 and tubulin and induced apoptosis with G2 cell-cycle arrest. The quaternary ammonium salt of compound 15j (compound 15js) exhibited excellent in vivo antitumor activity (TGI = 66.6%) in the HCT116 xenograft model with low toxicity. Indolopyrazinoquinazolinone derivatives represent promising multitargeting antitumor leads for the development of novel antitumor agents.
Xi:Irritant;
