52730-11-7

Basic information

• Product Name: (1R,8aS)-1-(furan-3-yl)-5,8a-dimethyl-1,7,8,8a-tetrahydro-3H-isochromen-3-one
• CAS NO: 52730-11-7
• Molecular Formula: C₁₅H₁₆O₃
• Molecular Weight: 244.2857
• Mol File: 52730-11-7.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 407.4°C at 760 mmHg
• Flash Point: 200.2°C
• Density: 1.18g/cm³
• Vapor Pressure: 7.55E-07mmHg at 25°C
• Refractive Index: 1.567
• CAS DataBase Reference: (1R,8aS)-1-(furan-3-yl)-5,8a-dimethyl-1,7,8,8a-tetrahydro-3H-isochromen-3-one(CAS DataBase Reference)
• NIST Chemistry Reference: (1R,8aS)-1-(furan-3-yl)-5,8a-dimethyl-1,7,8,8a-tetrahydro-3H-isochromen-3-one(52730-11-7)
• EPA Substance Registry System: (1R,8aS)-1-(furan-3-yl)-5,8a-dimethyl-1,7,8,8a-tetrahydro-3H-isochromen-3-one(52730-11-7)

Safety Data

• Hazardous Substances Data: 52730-11-7(Hazardous Substances Data)

Upstream product

• 40790-56-5 2,6-dimethyl-2-cyclohexen-1-one 
• 2816-57-1 2,6-dimethylcyclohexanone 
• 22037-28-1 3-bromofurane 
• 52528-87-7 1-Hydroxy-5,8a-dimethyl-1,7,8,8a-tetrahydro-isochromen-3-one 
• 95421-98-0 (E)-4-methyl-3,5-hexadienoic acid 
• 95421-96-8 ((1R,6S)-6-Formyl-2,6-dimethyl-cyclohex-2-enyl)-acetic acid methyl ester 
• 95421-99-1 cis-1β-(3-furyl)-1,4,4a,7,8,8a-hexahydro-5,8aα-dimethyl-3H-2-benzopyran-3-one 
• 52527-83-0 (5R,8aS)-1-Hydroxy-5,8a-dimethyl-1,5,6,7,8,8a-hexahydro-isochromen-3-one 
• 52580-71-9 Acetic acid (1S,5R,8aS)-5,8a-dimethyl-3-oxo-3,5,6,7,8,8a-hexahydro-1H-isochromen-1-yl ester 
• 118198-48-4 Acetic acid 5,8a-dimethyl-3-oxo-3,7,8,8a-tetrahydro-1H-isochromen-1-yl ester 
• 52528-86-6 Acetic acid (5S,8aS)-5-bromo-5,8a-dimethyl-3-oxo-3,5,6,7,8,8a-hexahydro-1H-isochromen-1-yl ester 

Relevant articles and documents

Total Synthesis of (+)-Granatumine A and Related Bislactone Limonoid Alkaloids via a Pyran to Pyridine Interconversion

We report the first total synthesis of (+)-granatumine A, a limonoid alkaloid with PTP1B inhibitory activity, in ten steps. Over the course of this study, two key methodological advances were made: a cost-effective procedure for ketone α,β-dehydrogenation using allyl-Pd catalysis, and a Pd-catalyzed protocol to convert epoxyketones to 1,3-diketones. The central tetrasubstituted pyridine is formed by a convergent Knoevenagel condensation and carbonyl-selective electrocyclization cascade, which was followed by a direct transformation of a 2H-pyran to a pyridine. These studies have led to the structural revision of two members of this family.

A Short Synthesis of dl-epi-Pyroangolensolide and dl-Pyroangolensolide: Confirmation of the Structures of Pyroangolensolide and Calodendrolide

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