52742-32-2

Basic information

• Product Name: [(dibenzylamino)oxy](phenyl)methanone
• CAS NO: 52742-32-2
• Molecular Formula: C₂₁H₁₉NO₂
• Molecular Weight: 317.3811
• Mol File: 52742-32-2.mol
• Article Data: 19

Chemical Properties

• Boiling Point: 465.4°C at 760 mmHg
• Flash Point: 235.3°C
• Density: 1.164g/cm³
• Vapor Pressure: 7.71E-09mmHg at 25°C
• Refractive Index: 1.617
• CAS DataBase Reference: [(dibenzylamino)oxy](phenyl)methanone(CAS DataBase Reference)
• NIST Chemistry Reference: [(dibenzylamino)oxy](phenyl)methanone(52742-32-2)
• EPA Substance Registry System: [(dibenzylamino)oxy](phenyl)methanone(52742-32-2)

Safety Data

• Hazardous Substances Data: 52742-32-2(Hazardous Substances Data)

Usage

Description

[(dibenzylamino)oxy](phenyl)methanone, with the molecular formula C21H19NO2, is a white to off-white solid that is soluble in organic solvents. This chemical compound is characterized by its unique structure, which includes a phenyl group attached to a methanone group, with a dibenzylaminooxy group connected to the phenyl ring. The dibenzylaminooxy group endows this compound with special properties and reactivity, making it a valuable intermediate in organic synthesis.

Uses

Used in Pharmaceutical Industry:
[(dibenzylamino)oxy](phenyl)methanone is used as a versatile reagent and intermediate for the production of various pharmaceuticals. Its unique structure and reactivity allow it to be involved in a wide range of chemical reactions and processes, contributing to the synthesis of different medicinal compounds.
Used in Agrochemical Industry:
Similarly, in the agrochemical industry, [(dibenzylamino)oxy](phenyl)methanone serves as an essential intermediate for the synthesis of various agrochemicals. Its properties and reactivity enable the creation of compounds that can be used in the development of pesticides, herbicides, and other agricultural products.
Safety Precautions:
It is crucial to handle and use [(dibenzylamino)oxy](phenyl)methanone with proper safety measures, as it may pose potential hazards and risks if mishandled. Adequate protective equipment and adherence to safety guidelines are necessary to minimize any risks associated with its use.

Upstream product

• 60-29-7 diethyl ether 
• 98-88-4 benzoyl chloride 
• 621-07-8 N,N-dibenzylhydroxylamine 
• 103-49-1 dibenzylamine 
• 94-36-0 dibenzoyl peroxide 
• 3376-26-9 N-Benzylidenebenzylamine N-oxide 
• 100-44-7 benzyl chloride 
• 622-30-0 N-benzyl hydroxylalmine 
• 65-85-0 benzoic acid 
• 100-52-7 benzaldehyde 

Downstream Products

• 780-25-6 N-benzylidene benzylamine 
• 65-85-0 benzoic acid 
• 621-07-8 N,N-dibenzylhydroxylamine 
• 93-89-0 benzoic acid ethyl ester 
• 10479-25-1 N,N-dibenzylethanamine 
• 91-73-6 N,N-dibenzylaniline 
• 55578-14-8 N-isopropyl-N,N-dibenzylamine 
• 30923-82-1 N,N-dibenzyl-2-methylpropan-2-amine 
• 620-40-6 tribenzylamine 
• 15429-21-7 N,N-dibenzyl-(4-chlorophenyl)amine 
• 18613-55-3 N,N-dibenzyl-4-anisidine 
• 52805-39-7 4-(N,N-dibenzylamino)benzonitrile 
• 151510-31-5 N-(2-nitrophenyl)dibenzylamine 
• 102910-19-0 N,N-dibenzylbicyclo[2.2.1]heptan-2-amine 

Relevant articles and documents

Triethyl Phosphite/Benzoyl Peroxide Mediated Reductive Dealkylation of O-Benzoylhydroxylamines: A Cascade Synthesis of Secondary Amides

A new triethyl phosphite/benzoyl peroxide (BPO) mediated system has been developed for the synthesis of secondary amides with good to excellent yields in a single step. This unprecedented cascade process involves sequential reduction of N–O bond and benzoylation followed by dealkylation of N–C bond of O-benzoylhydroxylamines (O-BHA). The methodology is versatile as it tolerates a variety of aromatic and aliphatic O-BHA as substrates to access secondary amides.

Direct N-O bond formation via oxidation of amines with benzoyl peroxide

Herein, we report a general and efficient method for direct N-O bond formation without undesirable C-N bond (amide) formation starting from commercially available amines and benzoyl peroxide. The oxidation of 1,2-diamines to furnish bis-(benzoyloxy)-1,2-diamines is reported for the first time. We found that a significant amount of water (BPO?:?water = 3?:?1) in combination with Cs2CO3 is necessary to achieve high selectivity and yield. The reaction conditions are applicable to a wide range of 1,2-diamine and 1,2-disubstituted-1,2-diamine substrates. Additionally this method is highly applicable to primary and secondary amines. Further, the present method can access chiral bis-hydroxamic acids and bis-hydroxyl amines in just two steps from 1,2-diamines. The reaction conditions are simple, mild and inert atmosphere free. The synthetic potential of this methodology is further demonstrated in the short synthesis of a chiral BHA ligand.

Copper-Catalyzed Electrophilic Ortho C(sp2)-H Amination of Aryl Amines: Dramatic Reactivity of Bicyclic System

A practical copper-catalyzed, 2-picolinamide-directed ortho C-H amination of anilines with benzoyl-protected hydroxylamines has been disclosed that proceeds smoothly without any external stoichiometric oxidant or additives. Remarkably, besides anilines, b