52805-34-2

Basic information

• Product Name: 4-BENZYLOXY-3-METHOXY-BENZONITRILE
• Synonyms: 4-BENZYLOXY-3-METHOXY-BENZONITRILE;AKOS B004385
• CAS NO: 52805-34-2
• Molecular Formula: C₁₅H₁₃NO₂
• Molecular Weight: 239.26922
• Product Categories: Aromatic Nitriles
• Mol File: 52805-34-2.mol
• Article Data: 21

Chemical Properties

• Boiling Point: 386.4±32.0 °C(Predicted)
• Appearance: /
• Density: 1.16±0.1 g/cm3(Predicted)
• CAS DataBase Reference: 4-BENZYLOXY-3-METHOXY-BENZONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-BENZYLOXY-3-METHOXY-BENZONITRILE(52805-34-2)
• EPA Substance Registry System: 4-BENZYLOXY-3-METHOXY-BENZONITRILE(52805-34-2)

Safety Data

• Hazardous Substances Data: 52805-34-2(Hazardous Substances Data)

Upstream product

• 2426-87-1 3-methoxy-4-(phenylmethoxy)benzaldehyde 
• 4421-08-3 3-methoxy-4-hydroxybenzonitrile 
• 100-44-7 benzyl chloride 
• 100-39-0 benzyl bromide 
• 4049-39-2 4-benzyloxy-3-hydroxy-benzaldehyde 
• 194985-94-9 3-hydroxy-4-(benzyloxy)benzonitrile 
• 121-33-5 vanillin 
• 52805-46-6 2-methoxy-5-cyanophenol 

Downstream Products

• 4421-08-3 3-methoxy-4-hydroxybenzonitrile 
• 1027201-30-4 C-(4-Benzyloxy-3-methoxy-phenyl)-C-phenyl-methyleneamine 
• 385784-84-9 4-(benzyloxy)-5-methoxy-2-nitrobenzonitrile 
• 385785-02-4 2-amino-4-(benzyloxy)-5-methoxybenzonitrile 
• 878376-17-1 7-(3-chloropropoxy)-N-[5-(3-fluorophenoxy)-1,3-thiazol-2-yl]-6-methoxyquinazolin-4-amine 
• 878376-18-2 7-(3-chloropropoxy)-N-{5-[(3-fluorobenzyl)thio]-1,3-thiazol-2-yl}-6-methoxyquinazolin-4-amine 
• 723282-92-6 N-(3-fluorophenyl)-2-(2-(7-(2-chloroethoxy)-6-methoxyquinazolin-4-yl-amino)-1,3-thiazol-5-yl)acetamide 
• 723278-29-3 2-(2-{[7-(3-chloropropoxy)-6-methoxyquinazolin-4-yl]amino}-1,3-thiazol-5-yl)-N-(3-fluorophenyl)acetamide 
• 878376-19-3 N-[(2-{[7-(3-chloropropoxy)-6-methoxyquinazolin-4-yl]amino}-1,3-thiazol-5-yl)methyl]-3-fluorobenzamide 
• 878376-16-0 N-[(2-{[7-(3-chloropropoxy)-6-methoxyquinazolin-4-yl]amino}-1,3-thiazol-5-yl)methyl]-3-fluorobenzenesulfonamide 
• 723281-45-6 2-(2-amino-1,3-thiazol-5-yl)-N-(2,3-difluorophenyl)acetamide-7-(3-chloropropoxy)-6-methoxyquinazoline 
• 723279-41-2 N-(3-fluorophenyl)-2-{2-[(7-{3-[(2-hydroxyethyl)amino]propoxy}-6-methoxyquinazolin-4-yl)amino]-1,3-thiazol-5-yl}acetamide 

Relevant articles and documents

Preliminary investigations into the synthesis and antimicrobial activities of boron-containing capsaicinoids

This preliminary study reports on the synthesis of two new boron-capsaicin derivatives containing either a short or long chain aliphatic tail group using an iridium catalyzed hydroboration reaction with pinacolborane. The boronate ester groups reside on the terminal position of the tail group and are necessary for the bioactivity of these compounds. Indeed, both compounds showed considerable activity against two Gram-positive bacteria, including Vancomycin-resistant Enterococcus. Vancomycin is considered the last resort medication for the treatment of septicemia, and new antibacterial agents that can treat sepsis are of paramount importance. The more lipophilic boron compound with the longer aliphatic chain also showed antifungal activity against Saccharomyces cerevisiae.

An alternative synthesis of Vandetanib (Caprelsa) via a microwave accelerated Dimroth rearrangement

Vandetanib is an orally available tyrosine kinase inhibitor used in the treatment of cancer. The current synthesis proceeds via an unstable 4-chloroquinazoline, using harsh reagents, in addition to requiring sequential protection and deprotection steps. In the present work, use of the Dimroth rearrangement in the key quinazoline forming step enabled the synthesis of Vandetanib in nine steps (compared to the previously reported 12–14).

Cellular Compositions Used To Restore Stem Cell or Progenitor Cell Function and Methods Related Thereto

This disclosure relates to compounds, compositions and methods of epigenetically transforming cells. In certain embodiments, the disclosure relates to methods of generating epigenetically altered cells comprising mixing isolated cells with compositions di